1983-72-8

Usage

Uses

Used in Pharmaceutical Industry:
MEDICAGOL is used as a therapeutic agent for its anti-inflammatory and antioxidant properties, potentially benefiting individuals with inflammatory conditions and oxidative stress-related disorders.
Used in Menopause Management:
MEDICAGOL is used as a hormone-like substance to alleviate menopausal symptoms, providing an alternative to traditional hormone replacement therapies.
Used in Osteoporosis Treatment:
MEDICAGOL is used as a bone health supplement to support the prevention and treatment of osteoporosis, due to its potential to improve bone density and strength.
Used in Oncology:
MEDICAGOL is used as an anti-cancer agent, particularly for its ability to inhibit cancer cell growth and proliferation, offering a potential therapeutic option for cancer patients.
Further research is needed to fully understand the potential therapeutic applications of MEDICAGOL and to explore its use across various industries and health conditions.

InChI:InChI=1/C16H8O6/c17-7-1-2-8-10(3-7)22-16(18)14-9-4-12-13(20-6-19-12)5-11(9)21-15(8)14/h1-5,17H,6H2

Upstream product

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• 54300-98-0 7-acetoxy-3-(6-acetoxy-benzo[1,3]dioxol-5-yl)-chromen-2-one 
• 5470-14-4 (6-bromobenzo[1,3]dioxol-5-yl)acetic acid 
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Relevant academic research and scientific papers

Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins

A copper-catalyzed intramolecular cross dehydrogenative C-O coupling reaction of 2′-hydroxyl-3-arylcoumarins was developed. This protocol provided a facile and efficient strategy for the construction of natural coumestans and derivatives in moderate to high yields. This transformation exhibited good functional group compatibility and was amenable to substrates with free phenolic hydroxyl groups.

O-heterocycles via laccase-catalyzed domino reactions with O2 as the oxidant

Laccase-catalyzed domino reactions of 4-hydroxy-6-methyl-2H-pyran-2-one or substituted 4-hydroxy-2H-chromen-2-ones with catechols using molecular oxygen as an oxidant afford coumestans and related O-heterocycles with yields ranging from 51% to 99%. Georg Thieme Verlag Stuttgart.

Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 μM) was selected for study of

The first direct transformation of 2,2'-dihydroxychalcones into coumestans

Three coumestans, flemichapparin, medicagol and sophoracoumestan B, are synthesised by direct reaction of the analogous 2,2'-dihydroxychalcones with thallium (III) nitrate in methanol.