1448522-49-3Relevant academic research and scientific papers
Oxidative kinetic resolution of heterocyclic sulfoxides with a porphyrin-inspired manganese complex by hydrogen peroxide
Yang, Jinchuang,Wang, Lianyue,Lv, Ying,Li, Ning,An, Yue,Gao, Shuang
, p. 156 - 159 (2017/12/15)
We have successfully reported here the low loading porphyrin-inspired high-valent manganese (IV)-oxo complex was applied in oxidative kinetic resolution (OKR) of racemic heterocyclic sulfoxides using the environmentally benign hydrogen peroxide for the first time. This approach allows for rapid OKR (0.5 h) of a variety of racemic sulfoxides (including pyridine, pyrimidine, pyrazine, thiazole, benzothiazole, thiophene) in excellent enantioselectivity (up to > 99% ee), simultaneously generating the corresponding sulfones in high yield (up to 80%). The catalytic system also showed an unexceptionable chemoselectivity for the sulfoxide substrates with hydroxyl groups in which only the sulfoxide group was oxidized. The practical utility of the method has been demonstrated in the OKR of gram-scale sulfoxides.
A nitrogen-containing four the tooth is organic biligand synthetic method
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Paragraph 0059; 0060; 0061, (2016/10/09)
A synthetic method for preparing a ligand with a chemical formula shown in the specification is provided. In the chemical formula, R1, R2 and R3 are hydrogen, alkyl, aryl, arylalkyl or alkoxyl, and are same or different, and X is O, S or N. The invention also discloses application of the ligand to combine with a transition metal for catalyzing asymmetric alkene epoxidation reaction.
Asymmetric epoxidation of alkenes catalyzed by a porphyrin-inspired manganese complex
Dai, Wen,Li, Jun,Li, Guosong,Yang, Hua,Wang, Lianyue,Gao, Shuang
, p. 4138 - 4141 (2013/09/12)
A novel strategy for catalytic asymmetric epoxidation of a wide variety of olefins by a porphyrin-inspired chiral manganese complex using H 2O2 as a terminal oxidant in excellent yield with up to greater than 99% ee has been successfully developed.
