1448776-35-9Relevant academic research and scientific papers
METHOD FOR PRODUCING 3,5-BIS(FLUOROALKYL)-PYRAZOL-4-CARBOXYLIC ACID DERIVATIVES AND 3,5-BIS(FLUOROALKYL)-PYRAZOLES
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Paragraph 0158-0160, (2015/02/18)
The present invention relates to novel 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and to a process for preparing 3,5-bis(fluoroalkyl)pyrazole-4-carboxylic acid derivatives and 3,5-bis(fluoroalkyl)pyrazoles.
A new synthesis and process development of bis(fluoroalkyl)pyrazoles as novel agrophores
Giornal, Florence,Landelle, Gregory,Lui, Norbert,Vors, Jean-Pierre,Pazenok, Sergiy,Leroux, Frederic R.
, p. 1002 - 1009 (2014/10/15)
The synthesis of 3,5-bis(fluoroalkyl)-pyrazoles as novel agrophores is described. Commercially available fluoroacetoacetates are treated with BF 3-activated TFEDMA affording in a straightforward one-pot sequence pyrazole carboxylates in good yields and with excellent regioselectivity. The carboxylate intermediates have been converted into the corresponding pyrazolic acids and submitted to decarboxylation, affording valuable building blocks for the design of novel bioactive ingredients. The found process is suitable for scale up and preparation of compounds in kilogram quantity.
A new life for an old reagent: Fluoroalkyl amino reagents as efficient tools for the synthesis of diversely fluorinated pyrazoles
Pazenok, Sergiy,Giornal, Florence,Landelle, Gregory,Lui, Norbert,Vors, Jean-Pierre,Leroux, Frederic R.
supporting information, p. 4249 - 4253 (2013/07/26)
Herein we describe the first practical method for the regioselective preparation of 3,5-bis(fluoroalkyl)pyrazoles. Starting from commercially available fluoroacetoacetates and by using (tetrafluoroethyl)dimethylamine as a convenient CF2H transfer reagent, this straightforward one-pot sequence affords highly substituted pyrazoles in good yields and excellent regioselectivity. Furthermore, these carboxylate intermediates were converted into the corresponding pyrazolic acids, which are valuable building blocks for the design of novel bioactive ingredients. Copyright
