1448809-26-4Relevant academic research and scientific papers
A three-component reaction between 1-substituted-2-methylimidazoles, cyanophenylacetylene, and various aldehydes: Stereoselective synthesis of (Z)-(2-cyano-1-phenyl)vinyl ethers of 2-(2-hydroxyalkyl)imidazoles
Trofimov, Boris A.,Andriyankova, Ludmila V.,Nikitina, Lina P.,Belyaeva, Kseniya V.,Mal'Kina, Anastasiya G.,Afonin, Andrei V.,Ushakov, Igor A.
supporting information, p. 4693 - 4696 (2013/08/23)
A three-component reaction between 1-substituted-2-methylimidazoles (1-Me, Bn), cyanophenylacetylene, and aliphatic (Me, i-Pr, n-Bu) and aromatic (Ph, 4-CN-, 4-O2N-C6H4) aldehydes occurs without a catalyst or solvent at room temperature (20-25 C) to afford stereoselectively (Z)-(2-cyano-1-phenyl)vinyl ethers of 2-hydroxyalkylimidazoles in 26-57% yields.
