603-86-1Relevant articles and documents
Preparation method of Eltrombopag
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Paragraph 0013; 0014, (2018/04/28)
The invention discloses a preparation method of Eltrombopag. The chemical name of Eltrombopag is 3-{(2Z)-2-[1-(3,4-xylyl)-3-methyl-5-oxo-1,5-dihydro-4H-parazole-4-ylidene]diazanyl}-2-hydroxy-3-biphenylcarboxylic acid-2-aminoethanol salt. The process of the preparation technique of the preparation method of Eltrombopag is simple, materials are easy to obtain, and the preparation method of Eltrombopag is cost-efficient and environment-friendly, can help realize industrialization, can promote the economic and technological development of the Eltrombopag active pharmaceutical ingredient, reduce the production cost, and is suitable for mass production.
An ortho-nitro phenol synthetic method of compound
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, (2016/10/10)
The invention relates to a synthesis method of o-nitrophenol compounds, solving the problems that production hazards are easily caused due to the release of a large deal of heat during the synthesis of o-nitrophenol and the severe environment pollution caused due to the generation of a large deal of waste gas and acid in the process in the prior art. The invention provides the synthesis method of the o-nitrophenol compounds, which comprises the steps: synthesizing 2-(phenoxy)pyridine from phenol compounds; and then sequentially adding 2-(phenoxy)pyridine and a catalyst, a nitrating reagent, an oxidant and an organic solvent into a sealed pressure container, heating and reacting for 10-50 hours in an oil bath of which the temperature is 80 DEG C-130 DEG C to obtain 2-(2-nitrophenyl)oxy pyridine; and finally treating to obtain o-nitrophenol. The synthesis method is simple, convenient and efficient.
Regioselective nitration of phenols and phenyl ethers using aluminium nitrate on silica as a nitrating system
Patil, Mahadeo R.,Mohite, Pravinkumar H.,Shisodia, Suresh,Keri, Rangappa S.
, p. 129 - 135 (2015/06/23)
Silica supported aluminum nitrate (Al(NO3)3·9H2O) was found to be an excellent reagent for the nitration of phenols and phenyl ethers. This procedure works efficiently on most of the examples at room temperature yielding nitro derivatives in fair to good yields with high regioselectivity. The present methodology evidenced a considerable enhancement in the reaction rate along with high o-selectivity, excellent yields, ease of handling and the simplicity in work up.
