1448902-54-2Relevant academic research and scientific papers
Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4- phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors
Mori, Yutaka,Ogawa, Yasuyuki,Mochizuki, Akiyoshi,Nakamura, Yuji,Fujimoto, Teppei,Sugita, Chie,Miyazaki, Shojiro,Tamaki, Kazuhiko,Nagayama, Takahiro,Nagai, Yoko,Inoue, Shin-Ichi,Chiba, Katsuyoshi,Nishi, Takahide
, p. 5907 - 5922 (2013/09/12)
We report synthesis and optimization of a series of (3S,5R)-5-(2,2- dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P1, P2 and P 3 portions led to a promising 3
