1449117-87-6

Basic information

• Product Name: (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-yl carbamate
• Synonyms: (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-yl carbamate
• CAS NO: 1449117-87-6
• Molecular Weight: 477.379
• Mol File: 1449117-87-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-yl carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-yl carbamate(1449117-87-6)
• EPA Substance Registry System: (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-yl carbamate(1449117-87-6)

Safety Data

• Hazardous Substances Data: 1449117-87-6(Hazardous Substances Data)

Upstream product

• 108473-13-8 (2E,4S)-4-<(tert-butyldimethylsilyl)oxy>-2-pentenol 
• 1449118-00-6 (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-ol 
• 3019-71-4 Trichloroacetyl isocyanate 
• 1449117-86-5 (S,E)-4-bromo-3-(4-((tert-butyldimethylsilyl)oxy)pent-2-en-1-yl)-1H-indole 
• 156617-45-7 (-)-(4R₂E)-4-tert-butyldimethylsilyloxy-2-pentenol 
• 52488-36-5 4-bromo-1H-indole 

Downstream Products

• 1449117-88-7 (R,E)-1-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-amine 
• 1449117-90-1 (2R,5R)-tert-butyl 2-((4-bromo-1-tosyl-1H-indol-3-yl)methyl)-5-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)-5,6-dihydropyridine-1(2H)-carboxylate 
• 1449117-91-2 C₄₁H₆₃BrN₂O₆SSi₂ 
• 1449117-97-8 (6aR,10aS)-di-tert-butyl 9-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)-6,6a-dihydroindolo[4,3-fg]quinoline-4,7(8H,10aH)-dicarboxylate 
• 67215-36-5 iso-lysergic acid methyl ester 
• 4579-64-0 lysergic acid methyl ester 

Relevant articles and documents

Erratum :Total synthesis of lysergic acid (Organic Letters (2014 ) 16:4 (1269-1269))

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Total synthesis of lysergic acid

A total synthesis of lysergic acid was accomplished. Key features of our synthesis include stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction, and a sequential process with a ring-closing metathesis and an intramolecular Heck reaction to construct the C and D rings.