1449117-91-2

Upstream product

• 1449118-00-6 (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-ol 
• 1449117-86-5 (S,E)-4-bromo-3-(4-((tert-butyldimethylsilyl)oxy)pent-2-en-1-yl)-1H-indole 
• 52488-36-5 4-bromo-1H-indole 
• 1449117-85-4 (4S)-4-benzyl-3-((2S)-1-hydroxy-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-en-1-yl)-5,5-dimethyloxazolidin-2-one 
• 1449117-84-3 (S)-4-benzyl-5,5-dimethyl-3-((S)-2-((S)-2,2,3,3,8,8,9,9-octamethyl-4,7-dioxa-3,8-disiladecan-5-yl)but-3-enoyl)oxazolidin-2-one 
• 102191-92-4 tert-butyldimethylsiloxyacetaldehyde 
• 1449117-83-2 (S)-4-benzyl-3-((S)-2-((S)-2-((tert-butyldimethylsilyl)oxy)-1-hydroxyethyl)but-3-enoyl)-5,5-dimethyloxazolidin-2-one 
• 1449117-88-7 (R,E)-1-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-amine 
• 1449117-87-6 (S,E)-5-(4-bromo-1-tosyl-1H-indol-3-yl)pent-3-en-2-yl carbamate 

Relevant academic research and scientific papers

Total synthesis of lysergic acid

A total synthesis of lysergic acid was accomplished. Key features of our synthesis include stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction, and a sequential process with a ring-closing metathesis and an intramolecular Heck reaction to construct the C and D rings.