1449118-00-6Relevant articles and documents
Erratum: Total synthesis of lysergic acid (Org. Lett. (2013) 15: 16 (4230-4233) DOI: 10.1021/ol4019562)
Umezaki, Satoshi,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 1269 - 1269 (2014/03/21)
-
Total synthesis of lysergic acid
Umezaki, Satoshi,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 4230 - 4233 (2013/09/12)
A total synthesis of lysergic acid was accomplished. Key features of our synthesis include stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction, and a sequential process with a ring-closing metathesis and an intramolecular Heck reaction to construct the C and D rings.