1449221-75-3

Upstream product

• 228728-08-3 6-Iodo-8-fluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester 
• 16419-60-6 2-Methylphenylboronic acid 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 101937-44-4 diethyl 2-((4-bromophenylamino)methylene)malonate 
• 79607-23-1 ethyl 6-bromo-4-oxo-1,4-dihydro-quinoline-3-carboxylate 
• 106-40-1 4-bromo-aniline 

Downstream Products

• 1449221-76-4 4-oxo-6-(o-tolyl)-1,4-dihydroquinoline-3-carboxylic acid 
• 1449221-47-9 N-(4-fluorobenzyl)-4-oxo-6-(o-tolyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-48-0 N-(3-fluorobenzyl)-4-oxo-6-(o-tolyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-50-4 4-oxo-6-(o-tolyl)-N-(4-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-55-9 4-oxo-6-(o-tolyl)-N-(3-(trifluoromethyl)benzyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-53-7 N-(3-bromobenzyl)-4-oxo-6-(o-tolyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-59-3 N-(furan-2-ylmethyl)-4-oxo-6-(o-tolyl)-1,4-dihydroquinoline-3-carboxamide 
• 1449221-52-6 N-cyclohexyl-4-oxo-6-(o-tolyl)-1,4-dihydroquinoline-3-carboxamide 

Relevant academic research and scientific papers

4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies

In this work, we report a series of new 4-oxo-1,4-dihydro-quinoline-3- carboxamide derivatives as β-secretase (BACE-1) inhibitors. Supported by docking study, a small library of derivatives were designed, synthesized and biologically evaluated in vitro. The studies revealed that the most potent analog 14e (IC50 = 1.89 μM) with low cellular cytotoxicity and high predicted blood brain barrier permeability, could serve as a good structure for further modification.

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.