1449307-87-2

Upstream product

• 75-91-2 tert.-butylhydroperoxide 
• 142266-67-9 N-benzyloxycarbonyl-1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 1260507-08-1 2(1H)-isoquinolinecarboxylic acid-3,4-dihydro-1-(2,4,6-trimethoxyphenyl)-phenylmethyl ester 
• 1449307-88-3 benzyl 1-(2,4-dimethoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-89-4 benzyl 1-(4-methoxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-90-7 benzyl 1-(2,4,6-trihydroxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-91-8 benzyl 1-(2-hydroxynaphthalen-1-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-92-9 benzyl 1-(4-hydroxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449308-13-7 benzyl 1-(2-hydroxyphenyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1260506-80-6 phenylmethyl-1-(1H-indol-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-93-0 benzyl 1-(1-methyl-1H-indol-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-94-1 benzyl 1-(2-methyl-1H-indol-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-95-2 benzyl 1-(3-methyl-1H-indol-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-96-3 benzyl 1-(5-bromo-2-methyl-1H-indol-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-97-4 benzyl 1-(5-cyano-2-methyl-1H-indol-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 
• 1449307-98-5 benzyl 1-(5-nitro-1H-indol-3-yl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 

Relevant academic research and scientific papers

Bronsted acid catalyzed C-H functionalization of N-protected tetrahydroisoquinolines via intermediate peroxides

An organocatalytic oxidative synthesis of N-protected tetrahydroisoquinolines is described by C-H functionalization via intermediate peroxides. The peroxides were synthesized from tert-butylhydroperoxide under metal-free thermal conditions and were converted into the final products by Bronsted acid catalyzed substitution. The nucleophile scope was investigated in detail and proved to be broad; N-deprotection of the coupling products could also be achieved. An organocatalytic oxidative synthesis of N-protected tetrahydroisoquinolines was achieved by C-H functionalization via Intermediate PeroxideS (CHIPS). The peroxides were synthesized under metal-free thermal conditions and were converted into the final products by reaction with a variety of nucleophiles by using Bronsted acid catalysis. Copyright