1449377-89-2Relevant academic research and scientific papers
Gold-catalyzed formal 1,6-acyloxy migration leading to 3,4-disubstituted pyrrolidin-2-ones
Hashmi, A. Stephen K.,Yang, Weibo,Yu, Yang,Hansmann, Max M.,Rudolph, Matthias,Rominger, Frank
, p. 1329 - 1332 (2013/03/14)
Mobile: The title reaction affords diastereomerically pure 3,4-disubstituted pyrrolidin-2-ones, which are important structural motifs in natural products, in good to high yields. Mechanistic investigations suggest the transformation proceeds through a tandem 1,3-acyloxy migration and a subsequent 1,5-acyloxy migration. DCE=1,2-dichloroethane, IPr=1,3-bis(2,6- diisopropylphenyl)imidazol-2-ylidene. Copyright
