1449384-89-7

Basic information

• Product Name: 3,6-di-O-benzoyl-α-mangostin
• Synonyms: 3,6-di-O-benzoyl-α-mangostin
• CAS NO: 1449384-89-7
• Molecular Weight: 618.683
• Mol File: 1449384-89-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3,6-di-O-benzoyl-α-mangostin(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-di-O-benzoyl-α-mangostin(1449384-89-7)
• EPA Substance Registry System: 3,6-di-O-benzoyl-α-mangostin(1449384-89-7)

Safety Data

• Hazardous Substances Data: 1449384-89-7(Hazardous Substances Data)

Upstream product

• 31271-10-0 6,8-dihydroxy-2-methoxy-1,7-bis(3-methylbut-2-en-1-yl)-9-oxo-9H-xanthen-3-yl acetate 
• 6147-11-1 α-mangostin 
• 1140525-42-3 1,3-dihydroxy-6-O-benzoyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone 
• 98-88-4 benzoyl chloride 
• 93-97-0 benzoic acid anhydride 

Downstream Products

• 1140525-42-3 1,3-dihydroxy-6-O-benzoyl-7-methoxy-2,8-bis(3-methyl-2-butenyl)-9-xanthone 
• 6147-11-1 α-mangostin 

Relevant articles and documents

High-purity α-mangostin process for the synthesis of

The invention relates to a synthesis process method of high-purity natural product alpha-mangostin, comprising the following steps: (1) reacting alpha-mangostin extracted through a process as an initial raw material with different acylation reagents in an alkaline solvent, recrystallizing to remove partial impurity to obtain phenolic hydroxy substituted alpha-mangostin with higher purity; (2) reacting the synthesized intermediate phenolic hydroxy substituted alpha-mangostin with different reagents in the solvent to remove protecting group, reverse extracting through acid-base, recrystallizing, decoloring, and further purifying to obtain the high-purity alpha-mangostin. The method provided by the invention is convenient to synthesize, high in yield, and capable of meeting the demand of the medicine to the quality.

Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs

A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL.