1449384-89-7Relevant academic research and scientific papers
High-purity α-mangostin process for the synthesis of
-
, (2018/01/19)
The invention relates to a synthesis process method of high-purity natural product alpha-mangostin, comprising the following steps: (1) reacting alpha-mangostin extracted through a process as an initial raw material with different acylation reagents in an alkaline solvent, recrystallizing to remove partial impurity to obtain phenolic hydroxy substituted alpha-mangostin with higher purity; (2) reacting the synthesized intermediate phenolic hydroxy substituted alpha-mangostin with different reagents in the solvent to remove protecting group, reverse extracting through acid-base, recrystallizing, decoloring, and further purifying to obtain the high-purity alpha-mangostin. The method provided by the invention is convenient to synthesize, high in yield, and capable of meeting the demand of the medicine to the quality.
Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana
Morelli, Carlo F.,Biagiotti, Marco,Pappalardo, Valeria M.,Rabuffetti, Marco,Speranza, Giovanna
supporting information, p. 750 - 755 (2015/12/24)
α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, but present in the molecule in multiple instances (three phenolic hydroxyl groups, two prenyl chains and two unsubstituted aromatic carbons). This study represents a first approach to the systematic investigation of the reactivity of α-mangostin and describes the semisynthesis of some minor xanthones isolated from G. mangostana.
Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
Sudta, Pichit,Jiarawapi, Payung,Suksamrarn, Apichart,Hongmanee, Poonpilas,Suksamrarn, Sunit
, p. 194 - 203 (2013/04/10)
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL.
