1140525-42-3Relevant articles and documents
High-purity α-mangostin process for the synthesis of
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, (2018/01/19)
The invention relates to a synthesis process method of high-purity natural product alpha-mangostin, comprising the following steps: (1) reacting alpha-mangostin extracted through a process as an initial raw material with different acylation reagents in an alkaline solvent, recrystallizing to remove partial impurity to obtain phenolic hydroxy substituted alpha-mangostin with higher purity; (2) reacting the synthesized intermediate phenolic hydroxy substituted alpha-mangostin with different reagents in the solvent to remove protecting group, reverse extracting through acid-base, recrystallizing, decoloring, and further purifying to obtain the high-purity alpha-mangostin. The method provided by the invention is convenient to synthesize, high in yield, and capable of meeting the demand of the medicine to the quality.
Potent activity against multidrug-resistant Mycobacterium tuberculosis of α-mangostin analogs
Sudta, Pichit,Jiarawapi, Payung,Suksamrarn, Apichart,Hongmanee, Poonpilas,Suksamrarn, Sunit
, p. 194 - 203 (2013/04/10)
A new series of mangostin analogs of natural α-mangostin from mangosteen was prepared and their antimycobacterial activity was evaluated in vitro against Mycobacterium tuberculosis H37Ra. The results showed that the monoalkyl tetrahydro α-mangostin analogs displayed increased antimycobacterial activity as compared with the lead natural xanthone, α-mangostin. Among the tested compounds, 6-methoxytetrahydro α-mangostin (16) exhibited the most potent antimycobacterial activity with minimum inhibitory concentration (MIC) of 0.78 μg/mL. The activity of the monoalkylated and monoacylated tetrahydro α-mangostins decreases as the length of carbon chain increases. The methyl ether analog was also active against the multidrug- resistant (MDR) strains with pronounced MICs of 0.78-1.56 μg/mL.