1449488-45-2Relevant academic research and scientific papers
Direct sulfenylation of imidazoheterocycles with disulfides in an iodine-hydrogen peroxide system
Ji, Xiao-Ming,Zhou, Shu-Juan,Chen, Fan,Zhang, Xing-Guo,Tang, Ri-Yuan
, p. 659 - 671 (2015/05/04)
Imidazoheterocycles undergo efficient and regioselective sulfenylation with disulfides using the iodine/hydrogen peroxide system in ethanol at 25 °C. This green strategy tolerates a wide range of functional groups to afford diverse sulfenylated imidazoheterocycles in high yields. Moreover, the fipronil (a pesticide) skeleton can be readily attached to imidazoheterocycles using this strategy, which is significant in drug development.
DMSO-POCl3: A reagent for methylthiolation of imidazo[1,2-a]pyridines and other imidazo-fused heterocycles
Patil, Shashikant M.,Kulkarni, Sarang,Mascarenhas, Malcolm,Sharma, Rajiv,Roopan, S. Mohana,Roychowdhury, Abhijit
, p. 8255 - 8262 (2013/09/02)
A practical and metal free method for methylthiolation of imidazo[1,2-a]pyridines and other imidazo-fused heterocycles using DMSO-POCl3 complex is reported. The reactions are carried out at room temperature that give the corresponding methylthiolated products in good to excellent yield. Further, its application to indole has been demonstrated.
