7008-63-1

Basic information

• Product Name: IMidazo[2,1-b]thiazole,6-phenyl-
• Synonyms: IMidazo[2,1-b]thiazole,6-phenyl-;6-phenyl-Imidazo[2,1-b]thiazole
• CAS NO: 7008-63-1
• Molecular Formula: C₁₁H₈N₂S
• Molecular Weight: 200.25962
• Mol File: 7008-63-1.mol
• Article Data: 33

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.29g/cm³
• Refractive Index: 1.712
• Storage Temp.: 2-8°C
• CAS DataBase Reference: IMidazo[2,1-b]thiazole,6-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: IMidazo[2,1-b]thiazole,6-phenyl-(7008-63-1)
• EPA Substance Registry System: IMidazo[2,1-b]thiazole,6-phenyl-(7008-63-1)

Safety Data

• Hazardous Substances Data: 7008-63-1(Hazardous Substances Data)

Usage

General Description

Imidazo[2,1-b]thiazole,6-phenyl- is a chemical compound with a molecular formula C11H8N2S. It is a heterocyclic compound containing both imidazole and thiazole rings, with a phenyl group attached at the 6-position. Imidazo[2,1-b]thiazole,6-phenyl- has been studied for its potential biological and pharmaceutical activities, with reported effects on various biological targets and pathways. Imidazo[2,1-b]thiazole,6-phenyl- has shown promise as a potential drug candidate for the treatment of various diseases, and its chemical structure makes it a valuable scaffold for the development of new therapeutic agents. It is used as a reagent in organic synthesis and medicinal chemistry research for the development of new pharmaceuticals.

InChI:InChI=1/C11H8N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-8H

Upstream product

• 96-50-4 2-thiazolylamine 
• 70-11-1 α-bromoacetophenone 
• 7664-93-9 sulfuric acid 
• 101496-48-4 2-(4-phenyl-1⁽³⁾H-imidazol-2-ylmercapto)-acetaldehyde-diethylacetal 
• 98-86-2 acetophenone 
• 100-41-4 ethylbenzene 
• 349481-08-9 ethyl 6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxylate 
• 752244-05-6 ethyl 6-phenylimidazo [2,1-b]thiazole-3-carboxylate 
• 613-91-2 acetophenone oxime 
• 19433-17-1 acetophenone O-acetyloxime 
• 6039-97-0 3H-thiazol-2-one 
• 389614-52-2 α-[(2,4-dinitrobenzene)sulfonyl]oxyacetophenone 
• 6857-34-7 4-phenyl-1,3-dihydro-2H-imidazole-2-thione 
• 55919-47-6 ethyl 2-bromo-3-oxo-3-phenylpropionate 

Downstream Products

• 14954-71-3 6-phenyl-5-phenylazo-imidazo[2,1-b]thiazole 
• 14954-66-6 5-(4-nitro-phenylazo)-6-phenyl-imidazo[2,1-b]thiazole 
• 14956-60-6 5-(2-nitro-phenylazo)-6-phenyl-imidazo[2,1-b]thiazole 
• 74630-73-2 6-phenylimidazo[2,1-b]thiazole-5-carbaldehyde 
• 14956-61-7 5-(3-nitro-phenylazo)-6-phenyl-imidazo[2,1-b]thiazole 
• 16311-29-8 N,N''-(6-phenyl-imidazo[2,1-b]thiazole-2,5-diyl)-bis-hydrazine-N,N'-dicarboxylic acid tetraethyl ester 
• 93327-30-1 4-(6-phenyl-imidazo[2,1-b]thiazol-5-ylazo)-benzenesulfonic acid 
• 99866-35-0 5-bromo-6-phenylimidazo[2,1-b]thiazole 
• 99866-92-9 2-nitroso-6-phenyl-imidazo[2,1-b]thiazole 
• 16311-38-9 5-nitro-6-(4-nitro-phenyl)-imidazo[2,1-b]thiazole 
• 7120-14-1 6-p-nitrophenylimidazo<2,1-b>thiazole 
• 16311-34-5 5-nitroso-6-phenylimidazo[2,1-b][1,3]thiazole 
• 1395225-77-0 N-phenyl-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine 
• 1395225-82-7 N-(4-chlorophenyl)-4-(6-phenylimidazo[2,1-b]thiazol-5-yl)thiazol-2-amine 

Relevant articles and documents

Synthesis, crystal structure, antimicrobial activity and docking studies of new imidazothiazole derivatives

A series of imidazothiazole derivatives were synthesized via Claisen–Schmidt condensation of aldehyde 3, and different methyl ketones and their chemical structures were confirmed using 13C NMR, 1H NMR and LC–MS. In addition, the mole

Electrochemical Oxidative C3 Acyloxylation of Imidazo[1,2- a]pyridines with Hydrogen Evolution

The C3-functionalized imidazo[1,2-a]pyridines are versatile nitrogen-fused heterocycles; however, the methods for the C3 acyloxylation of imidazo[1,2-a]pyridines have never been reported. Herein we demonstrate the electrochemical oxidative C3 acyloxylation of imidazo[1,2-a]pyridines for the first time. Notably, by using electricity, the electrochemical oxidative C3 acyloxylation of imidazo[1,2-a]pyridines was carried out under mild conditions. Moreover, in addition to aromatic carboxylic acids, alkyl carboxylic acids were also competent substrates.

New imidazo[2,1-: B] thiazole-based aryl hydrazones: Unravelling their synthesis and antiproliferative and apoptosis-inducing potential

Herein, we have designed and synthesized new imidazo[2,1-b]thiazole-based aryl hydrazones (9a-w) and evaluated their anti-proliferative potential against a panel of human cancer cell lines. Among the synthesized compounds, 9i and 9m elicited promising cytotoxicity against the breast cancer cell line MDA-MB-231 with IC50 values of 1.65 and 1.12 μM, respectively. Cell cycle analysis revealed that 9i and 9m significantly arrest MDA-MB-231 cells in the G0/G1 phase. In addition, detailed biological studies such as annexin V-FITC/propidium iodide, DCFH-DA, JC-1 and DAPI staining assays revealed that 9i and 9m triggered apoptosis in MDA-MB-213 cells. Overall, the current work demonstrated the cytotoxicity and apoptosis-inducing potential of 9i and 9m in breast cancer cells and suggested that they could be explored as promising antiproliferative leads in the future. This journal is