1449507-53-2

Upstream product

• 1449507-52-1 C₁₅H₈Br₂S₅ 
• 589-87-7 1,4-bromoiodobenzene 
• 1025762-66-6 3-(1H-indazol-5-yl)-2,2-dimethyl-3-phenylpropanoic acid 
• 40365-64-8 hexa-4,5-dien-1-ol 
• 1438394-24-1 N-benzyl-1-oxo-N-(penta-3,4-dien-1-yl)indane-2-carboxamide 

Downstream Products

• 1463472-28-7 C₃₀H₁₆Br₄S₈ 

Relevant academic research and scientific papers

Synthesis and photoinduced electron transfer in platinum(ii) bis(N-(4-ethynylphenyl)carbazole)bipyridine fullerene complexes

Platinum(ii) bis(N-(4-ethynylphenyl)carbazole)bipyridine fullerene complexes, (Cbz)2-Pt(bpy)-C60 and (tBuCbz)2-Pt(bpy)-C60, were synthesized. Their photophysical properties were studied by electronic absorption and emission spectroscopy and the origin of the transitions was supported by computational studies. The electrochemical properties were also studied and the free energies for charge-separation and charge-recombination processes were evaluated. The photoinduced electron transfer reactions in the triads were investigated by femtosecond and nanosecond transient absorption spectroscopy. In dichloromethane, both triads undergo ultrafast charge separation from the 3MLCT/LLCT excited state within 300 fs to yield their respective triplet charge-separated (CS) states, namely (Cbz)2+-Pt(bpy)-C60- and (tBuCbz)2+-Pt(bpy)-C60-, and the CS states would undergo charge recombination to give the 3C60 state, which subsequently decays to the ground state in 22-28 μs. This journal is

The structure-activity relationships of L3MBTL3 inhibitors: Flexibility of the dimer interface

We recently reported the discovery of UNC1215, a potent and selective chemical probe for the L3MBTL3 methyllysine reader domain. In this article, we describe the development of structure-activity relationships (SAR) of a second series of potent L3MBTL3 antagonists which evolved from the structure of the chemical probe UNC1215. These compounds are selective for L3MBTL3 against a panel of methyllysine reader proteins, particularly the related MBT family proteins, L3MBTL1 and MBTD1. A co-crystal structure of L3MBTL3 and one of the most potent compounds suggests that the L3MBTL3 dimer rotates about the dimer interface to accommodate ligand binding.

Molecular and crystal structure diversity, and physical properties of tetrathiafulvalene derivatives substituted with various aryl groups through sulfur bridges

A library of tetrathiafulvalene (TTF) derivatives (TTF-1-TTF-47) bearing aryl groups attached through sulfur bridges has been created. The peripheral aryl groups exert a significant influence on both the electronic and crystallographic properties of the resulting TTFs. These TTFs display broad absorption bands at 400-500 nm caused by intramolecular charge-transfer transitions between the aryl groups and central TTF core, and their first redox potentials increase with increasing electron-withdrawing ability of the aryl groups. In their crystal structures (22 examples), the central TTF cores adopt various conformations, including chair, half-chair, boat, and planar conformations. Moreover, the peripheral aryl groups exhibit multiple alignment modes with respect to the central TTF core, caused by their rotation about the two C-S bonds of the sulfur bridges. The packing motifs of these TTFs depend on both the nature of the aryl groups and their spatial alignment modes. Driven by intermolecular van der Waals forces and π-π interactions between the aryl groups and between the aryl groups and the TTF core, these TTFs adopt various packing structures. As a typical example, TTF-14, an achiral molecule, adopts a helical chain stack through intermolecular atomic close contacts. Moreover, the molecular geometries and packing motifs of these TTFs are sensitive to environmental variation, as exemplified by TTF-28, which adopts three distinct crystal modifications with diverse molecular geometries and stacking modes under different crystallization conditions. This work indicates that these TTFs are potential candidates as electronic materials, as well as functional building blocks for supramolecular assembly. Structural diversity due to flexible linkers: A thorough investigation of the properties and structural diversity of tetrathiafulvalene (TTF) derivatives substituted with various aryl groups through sulfur bridges is reported (see graphic). The aryl groups significantly affect both the electronic and crystallographic properties of the TTFs. These TTFs are candidates as electronic materials, as well as functional building blocks for supramolecular assembly. Copyright

Straightforward access to aryl-substituted/fused 1,3-dithiole-2- chalcogenones by Cu-catalyzed C-S coupling between aryl iodides and zinc-thiolate complex (TBA)2[Zn(DMIT)2]

The Cu-catalyzed C-S coupling between iodoaryl and a zinc-thiolate complex was achieved. This protocol provides a facile and efficient synthetic approach for aryl-substituted/fused 1,3-dithiole-2-chalcogenones, which can be converted to TTFs. The Royal Society of Chemistry 2013.