1438394-24-1Relevant articles and documents
Enantio- and diastereoselective palladium catalysed arylative and vinylative allene carbocyclisation cascades
Li, Meiling,Hawkins, Alison,Barber, David M.,Bultinck, Patrick,Herrebout, Wouter,Dixon, Darren J.
, p. 5265 - 5267 (2013/06/27)
The enantioselective synthesis of heavily decorated spirolactams has been accomplished via an arylative or vinylative allene carbocyclisation cascade. Mediated by silver phosphate, a range of allene-linked pro-nucleophiles and aryl or vinyl iodides were reacted in the presence of catalytic Pd(OAc)2 and chiral bis(oxazoline) ligands to afford the spirolactam products in good yields and high enantio- and diastereoselectivities. The Royal Society of Chemistry 2013.