1449566-18-0Relevant academic research and scientific papers
Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives
Farouk, Mahmoud,Alrokayan, Salman A.,Imran, Ahamad,Abu-Salah, Khalid M.,Ghazzali, Mohamed,Al-Farhan, Khalid A.,El-Gohary, Salem,Adly, Mamdouh
, p. 229 - 235 (2013/05/21)
3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II-III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV-XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII-XIX.
