908083-85-2Relevant academic research and scientific papers
Facile synthesis of 3-substituted quinazoline-2,4-dione and 2,3-di-substituted quinazolinone derivatives
Farouk, Mahmoud,Alrokayan, Salman A.,Imran, Ahamad,Abu-Salah, Khalid M.,Ghazzali, Mohamed,Al-Farhan, Khalid A.,El-Gohary, Salem,Adly, Mamdouh
, p. 229 - 235 (2013)
3-Substituted quinazoline-2,4(1H,3H)-dione and 2,3-di-substituted quinazolineone derivatives attract considerable interest due to their pharmacological properties. In this paper, we report the synthesis of N-substituted-3-nitrophthalimide derivatives II-III, the reactions of phthalimide III with amines, hydrazines, and amino acid derivatives to synthesise a small library of 3-substituted-5-nitroquinazoline-2,4(1H,3H)-diones IV-XIV and 2,3-di-substituted-6-nitro-quinazolineones XVIII-XIX.
One-pot synthesis and luminescent spectra of 3-allyl substituted quinazoline-2,4-dione derivatives as allyl capping agents
Farouk, Mahmoud,Alrokayan, Salman A.,Imran, Ahamad,Abu-Salah, Khalid M.
scheme or table, p. 75 - 78 (2012/04/04)
3-Nitro-N-(phenylsulphonyloxy)phthalimide (IIIa) and N-(phenylsulphonyloxy) phthalimide (IIIb) were synthesised as key intermediates in good yield. Their structures were confirmed by 1H NMR and FTIR spectral data. The reaction of the key intermediates with allylamine produced 3-allyl-5- nitroquinazoline-2,4-(1H,3H)-dione (IVa) and 3-allylquinazoline-2,4-(1H,3H)- dione (IVb), respectively. Luminescence emission and excitation spectra of IVa and IVb are also presented.
