1449787-47-6

Basic information

• Product Name: (1-(1-hydroxy-1H-pyrazol-4-yl)-1H-pyrrol-3-yl)(phenyl)methanone
• Synonyms: (1-(1-hydroxy-1H-pyrazol-4-yl)-1H-pyrrol-3-yl)(phenyl)methanone
• CAS NO: 1449787-47-6
• Molecular Weight: 253.26
• Mol File: 1449787-47-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1-(1-hydroxy-1H-pyrazol-4-yl)-1H-pyrrol-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (1-(1-hydroxy-1H-pyrazol-4-yl)-1H-pyrrol-3-yl)(phenyl)methanone(1449787-47-6)
• EPA Substance Registry System: (1-(1-hydroxy-1H-pyrazol-4-yl)-1H-pyrrol-3-yl)(phenyl)methanone(1449787-47-6)

Safety Data

• Hazardous Substances Data: 1449787-47-6(Hazardous Substances Data)

Upstream product

• 1449787-54-5 (1-(1-(benzyloxy)-1H-pyrazol-4-yl)-1H-pyrrol-3-yl)(phenyl)methanone 
• 229171-07-7 1-(benzyloxy)-4-iodo-1H-pyrazole 
• 7126-41-2 3-benzoylpyrrole 
• 1449787-57-8 1-(benzyloxy)-4-(1H-pyrrol-1-yl)-1H-pyrazole 

Relevant articles and documents

1-Hydroxypyrazole as a bioisostere of the acetic acid moiety in a series of aldose reductase inhibitors

Therapeutic intervention with aldose reductase inhibitors appears to be promising for major pathological conditions (i.e., long-term diabetic complications and inflammatory pathologies). So far, however, clinical candidates have failed due to adverse side-effects (spiroimides) or poor bioavailability (carboxylic acids). In this work, we succeeded in the bioisosteric replacement of an acetic acid moiety with that of 1-hydroxypyrazole. This new scaffold appears to have a superior physicochemical profile, while attaining inhibitory activity in the submicromolar range.