14502-76-2

Usage

Chemical Properties

White Solid

Upstream product

• 629-03-8 1 ,6-dibromohexane 
• 24566-79-8 2-(6-bromohexyl)isoindole-1,3-dione 
• 4048-33-3 6-amino-1-hexanol 

Downstream Products

• 21679-18-5 thiosulfuric acid S-(6-amino-hexyl ester) 
• 116784-97-5 N-benzyloxycarbonyl-6-bromo-1-hexylamine 
• 142356-33-0 tert-butyl 6-bromohexylcarbamate 
• 116784-99-7 N-<(benzyloxy)carbonyl>-N'-(2-furoyl)-N'-methyl-1,6-hexanediamine 
• 116784-98-6 N-<(benzyloxy)carbonyl>-N'-methyl-1,6-hexanediamine 
• 14502-43-3 8-aminooct-1-yne 

Relevant academic research and scientific papers

Hybridizing ability and nuclease resistance profile of backbone modified cationic phosphorothioate oligonucleotides

Various stereochemically pure cationic phosphorothioate oligonucleotides bearing aminoalkyl moieties were synthesized, and their duplex-forming ability against single-stranded DNA (ssDNA), single-stranded RNA (ssRNA) and triplex-forming ability against do

OLIGONUCLEOTIDE COMPOSITIONS AND METHODS THEREOF

The present disclosure provides modified oligonucleotides and compositions and methods thereof. In some embodiments, provided technologies comprise modified sugars and/or modified internucleotidic linkages. In some embodiments, the present disclosure provides technologies for preparing modified oligonucleotides. In some embodiments, the present disclosure provides chirally controlled oligonucleotide compositions and methods for their preparation and uses.

High-Yielding Water-Soluble Asymmetric Cyanine Dyes for Labeling Applications

A simple and efficient microwave-assisted synthesis of asymmetric pentamethine cyanine dyes with various functional groups was developed, which allows high-yielding results. The synthesized dyes are modifiable and suitable for single-molecule imaging in biological and medical sciences by application of click chemistry or classic esterification and amidation.

THERAPEUTIC METAL COMPLEXES AND LIGANDS AND METHODS OF MAKING AND USING SAME

Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.

NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS

Provided are mucolytic compounds that are more effective, and/or absorbed less rapidly from mucosal surfaces, and/or are better tolerated as compared to N-acetylcysteine (NAC) and DTT. The compounds are represented by compounds of Formula I which embrace structures (la)-(Ib), where the structural variables are as defined herein.

MACROCYCLIC COMPOUNDS AS IRAK4 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein i.a. Ring A is phenylene or 5- to 6-membered heteroarylene; Ring B is phenylene, 5- to 6-membered heterocycloalkylene or 5- to 6-membered heteroarylen; R4/s

An acyl-SAM analog as an affinity ligand for identifying quorum sensing signal synthases

N-Acylhomoserine lactones (AHLs) are quorum sensing signals produced by Gram-negative bacteria. We here report the affinity purification of AHL synthases using beads conjugated with an enzyme inhibitor, which was designed based on the catalytic intermediate acyl-SAM. the Partner Organisations 2014.