145041-21-0

Basic information

• Product Name: (S)-methyl 2-(2-acetoxypropanamido)benzoate
• Synonyms: (S)-methyl 2-(2-acetoxypropanamido)benzoate
• CAS NO: 145041-21-0
• Molecular Weight: 265.266
• Mol File: 145041-21-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-methyl 2-(2-acetoxypropanamido)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 2-(2-acetoxypropanamido)benzoate(145041-21-0)
• EPA Substance Registry System: (S)-methyl 2-(2-acetoxypropanamido)benzoate(145041-21-0)

Safety Data

• Hazardous Substances Data: 145041-21-0(Hazardous Substances Data)

Upstream product

• 535-17-1 (S)-2-acetoxypropionic acid 
• 36394-75-9 (S)-2-acetoxypropanoyl chloride 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 145057-52-9 8-Methoxy-6,9-dimethyl-9-phenyl-8-trimethylsilanyloxy-9,10-dihydro-6H,8H-7-oxa-5,10,10a-triaza-cyclohepta[b]naphthalen-11-one 
• 145041-20-9 6,9-Dimethyl-9-phenyl-9,10-dihydro-6H-7-oxa-5,10,10a-triaza-cyclohepta[b]naphthalene-8,11-dione 
• 145041-19-6 2-[2-((S)-1-Hydroxy-ethyl)-4-oxo-4H-quinazolin-3-ylamino]-2-phenyl-propionic acid 
• 141236-02-4 2-[2-((S)-1-Hydroxy-ethyl)-4-oxo-4H-quinazolin-3-ylamino]-2-phenyl-propionic acid methyl ester 

Relevant articles and documents

Preparation method and application of 2-lactoyl aminobenzoic acid

The invention relates to a new medicinal application of a chiral compound. The chiral compound is chemically named as R-/S-2-lactoyl aminobenzoic acid and has a structural formula as follows: formula (shown in the description). The compound is initially extracted and separated from secondary metabolite of microorganisms and can be obtained by virtue of a chemical synthetic method. An initial pharmacology experiment shows that the compound has good pain-easing and anti-inflammation activities and relatively low stimulation to gastrointestinal tracts. Recent researches prove that the compound has relatively good anti-platelet aggregation and anti-thrombus activities and is expected to be a novel non-steroidal anti-platelet aggregation and anti-thrombus drug.

Amination with 3-acetoxyaminoquinazolin-4-(3H)ones: Preparation of α-aminoacid esters by reaction with silyl ketene acetals followed by N-N bond cleavage

Solutions of 3-acetoxyaminoquinazoline (5) react with enol ethers and silyl ketene acetals to give α-aminoaldehyde α-aminoketone or α-aminoacid derivatives. Acylation of the exocyclic nitrogen in these derivatives, as a preliminary to reductive N-N bond cleavage, could only be accomplished by indirect means. Samarium diiodide, however, effected the reduction of this N-N bond without the necessity for N-acylation. Solutions of the corresponding enantiopure 3-acetoxyaminoquinazolinone (34) brought about the disastereoselective amination of the prochiral silyl ketene acetal (15) and reductive N-N bond cleavage of the major disastereoisomer lead to enantiopure 2-phenylalanine methyl ester.