145046-84-0

Basic information

• Product Name: 4'-<(2-butyl-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl)methyl>biphenyl-2-carbonitrile
• Synonyms: 4'-<(2-butyl-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl)methyl>biphenyl-2-carbonitrile
• CAS NO: 145046-84-0
• Molecular Weight: 382.465
• Mol File: 145046-84-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4'-<(2-butyl-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl)methyl>biphenyl-2-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-<(2-butyl-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl)methyl>biphenyl-2-carbonitrile(145046-84-0)
• EPA Substance Registry System: 4'-<(2-butyl-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl)methyl>biphenyl-2-carbonitrile(145046-84-0)

Safety Data

• Hazardous Substances Data: 145046-84-0(Hazardous Substances Data)

Upstream product

• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 133052-28-5 2-butyl-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridine 
• 153953-01-6 N-(4-amino-2-chloro-3-pyridyl)pentanamide 
• 145047-33-2 2-butyl-4-chloro-3-(2'-cyanobiphenyl-4-ylmethyl)-3H-imidazo[4,5-c]pyridine 
• 153953-00-5 N-(4-amino-2-chloro-3-pyridyl)-N-<(2'-cyano-4-biphenyl)methyl>pentanamide 
• 109-52-4 valeric acid 
• 145047-34-3 2-butyl-4-chloro-3H-imidazo<4,5-c>pyridine 
• 2082-59-9 pentanoic anhydride 
• 39217-08-8 2-chloropyridine-3,4-diamine 

Downstream Products

• 156221-84-0 2-<<2-butyl-3-<(2'-cyano-4-biphenylyl)methyl>-4,5-dihydro-4-oxo-3H-imidazo<4,5-c>pyridin-5-yl>methyl>benzoic acid, ethyl ester 
• 156222-03-6 2-butyl-4,5-dihydro-4-oxo-3-[2'-(tetrazol-5-yl)-biphenyl-4-ylmethyl]-5-(o-ethoxycarbonyl-benzyl)-3H-imidazo[4,5-c]-pyridine 
• 145047-27-4 2-Butyl-5-(2-nitro-benzyl)-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,5-dihydro-imidazo[4,5-c]pyridin-4-one 
• 156222-09-2 2-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3,4-dihydro-imidazo[4,5-c]pyridin-5-yl}-N,N-diethyl-acetamide 
• 156221-96-4 4'-<<2-butyl-4,5-dihydro-5-<(N-methyl-N-phenylcarbamoyl)-methyl>-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl>methyl>biphenyl-2-carbonitrile 
• 156221-95-3 4'-<<2-butyl-4,5-dihydro-5-<(2-oxo-2-pyrrolidino)ethyl>-4-oxo-3H-imidazo<4,5-c>pyridin-3-yl>methyl>biphenyl-2-carbonitrile 
• 156250-38-3 4'-<<2-butyl-4,5-dihydro-4-oxo-5-<(N-phenylcarbamoyl)-methyl>-3H-imidazo<4,5-c>pyridin-3-yl>methyl>biphenyl-2-carbonitrile 

Relevant articles and documents

Imidazopyridines

Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.

Process for the preparation of imidazopyridines

The invention relates to a novel process for the preparation of imidazopyridines of formula I: STR1 in which R is an alkyl having 1-6 C atoms, characterized in that 3,4-diamino-2-chloropyridine (II) is reacted with an acid anhydride of the formula RCO--O--COR 40 (III), in which R is as defined and R' is R or can be another aliphatic or aromatic radical, to give a 4-amino-2-chloro-3-R-CO-aminopyridine (IV), this is converted with 4'-bromomethyl-2-cyanobiphenyl (V), in the presence of an alkali metal alcoholate in an inert solvent, to a 4-amino-2-chloro-3-R-CO-[N-(2'-cyano-biphenyl-4-ylmethyl)-amino]pyridine (VI) and this is treated with a strong acid, a 2-R-4-chloro-3-(2'-cyano-biphenyl-4-ylmethyl)-3H-imidazo[4,5-c]pyridine (VII) being formed as an intermediate.