145050-19-7

Upstream product

• 145050-18-6 2-(2-methylallyl)-malononitrile 
• 103366-35-4 Acetic acid (2R,3R)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-2-yl ester 

Downstream Products

• 145050-22-2 (6R,7R)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester 
• 145050-22-2 (6R,7S)-5,5-Dicyano-3-methyl-7-{[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amino}-8-oxo-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester 
• 145307-08-0 Sodium; (6R,7S)-5,5-dicyano-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 145050-20-0 [(2R,3R)-2-(1,1-Dicyano-3-oxo-butyl)-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-oxo-acetic acid allyl ester 
• 145050-21-1 (6R,7R)-5,5-Dicyano-3-methyl-8-oxo-7-(2-phenoxy-acetylamino)-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid allyl ester 

Relevant academic research and scientific papers

Synthesis of a highly reactive 1,1-dicyanomethylene-1-dethiacephalosporin

Synthesis of the 1,1-dicyanomethylene-1-dethiacephalosporin 1a is described. Substitution of the dicyanomethylene moiety for sulfur at position 1 of the cephem nucleus resulted in a highly reactive β-lactam antibacterial.