Synthesis of a highly reactive 1,1-dicyanomethylene-1-dethiacephalosporin

Article abstract of DOI:10.1016/S0040-4039(00)60017-5

Synthesis of the 1,1-dicyanomethylene-1-dethiacephalosporin 1a is described. Substitution of the dicyanomethylene moiety for sulfur at position 1 of the cephem nucleus resulted in a highly reactive β-lactam antibacterial.