Tetrahedron Letters p. 6103 - 6106 (1992)
Update date:2022-08-03
Topics:
Dunlap
Dezube
Keith
Weigele
Synthesis of the 1,1-dicyanomethylene-1-dethiacephalosporin 1a is described. Substitution of the dicyanomethylene moiety for sulfur at position 1 of the cephem nucleus resulted in a highly reactive β-lactam antibacterial.
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