Synthesis of a highly reactive 1,1-dicyanomethylene-1-dethiacephalosporin

DOI: 10.1016/S0040-4039(00)60017-5

Source and publish data:

Tetrahedron Letters p. 6103 - 6106 (1992)

Update date:2022-08-03

Topics:

Authors:

Dunlap Dunlap

Dezube Dezube

Keith Keith

Weigele Weigele

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Article abstract of DOI:10.1016/S0040-4039(00)60017-5

Synthesis of the 1,1-dicyanomethylene-1-dethiacephalosporin 1a is described. Substitution of the dicyanomethylene moiety for sulfur at position 1 of the cephem nucleus resulted in a highly reactive β-lactam antibacterial.

Full text of DOI:10.1016/S0040-4039(00)60017-5

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Product name:N-[(2R,3R)-2-(1,1-Dicyano-3-methyl-but-3-enyl)-4-oxo-azetidin-3-yl]-2-phenoxy-acetamide

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