1450657-43-8

Basic information

• Product Name: (S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene
• Synonyms: (S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene
• CAS NO: 1450657-43-8
• Molecular Weight: 299.351
• Mol File: 1450657-43-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene(1450657-43-8)
• EPA Substance Registry System: (S)-4-(1-azido-2-(methylsulfonyl)ethyl)-2-ethoxy-1-methoxybenzene(1450657-43-8)

Safety Data

• Hazardous Substances Data: 1450657-43-8(Hazardous Substances Data)

Upstream product

• 31526-71-3 3-ethoxy-4-methoxy-acetophenone 
• 1131-52-8 3-ethoxy-4-methoxybenzaldehyde 
• 1450657-28-9 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-one 

Downstream Products

• 608141-43-1 (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine-(S)-2-acetamido-4-methylpentanoate 
• 608141-42-0 (S)-2-[1 (3-ethoxy-4-methoxyphenyl)]-1-methanesulfonyl-2-ethylamine 

Relevant articles and documents

A SYNTHETIC PATHWAY TOWARDS APREMILAST

The present invention relates to an asymmetric process for providing N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (apremilast) or a pharmaceutically acceptable salt or solvate thereof.

A NOVEL SYNTHETIC PATHWAY TOWARDS APREMILAST

The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.