145066-06-4

Basic information

• Product Name: bromo(chloromethyl)bis(4-fluorophenyl)germane
• CAS NO: 145066-06-4
• Molecular Weight: 392.166
• Mol File: 145066-06-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bromo(chloromethyl)bis(4-fluorophenyl)germane(CAS DataBase Reference)
• NIST Chemistry Reference: bromo(chloromethyl)bis(4-fluorophenyl)germane(145066-06-4)
• EPA Substance Registry System: bromo(chloromethyl)bis(4-fluorophenyl)germane(145066-06-4)

Safety Data

• Hazardous Substances Data: 145066-06-4(Hazardous Substances Data)

Upstream product

• 21572-18-9 trichloro(chloromethyl)germane 
• 352-13-6 4-flourophenylmagnesium bromide 

Downstream Products

• 145066-07-5 (chloromethyl)bis(4-fluorophenyl)methylgermane 

Relevant articles and documents

Bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane, a germanium analogue of the agricultural fungicide flusilazole: synthesis and biological properties

Bis(4-fluorophenyl)methyl(1H-1,2,4-triazol-1-yl-methyl)germane (2), a germanium analogue of the agricultural fungicide flusilazole (1), has been synthesized from Cl3GeCH2Cl (3) by both a three-step and a four-step synthesis (3 (p-F-C6H4)2Ge(CH2Cl)Br (4) (p-F-C6H4)2Ge(CH2Cl)CH3 (5) 2; 5 (p-F-C6H4)2Ge(CH2I)CH3 (6) 2).The fungicidal properties of 2 have been compared with those of the parent silicon compound 1 (studies on Si/Ge bioisosterism).In various test systems, the Si/Ge analogues 1 and 2 showed comparable fungicidal properties (in activityagainst plant pathogenic fungi; in agar plate diffusion tests and greenhouse evaluations; in activity against human pathogenic fungi; in serial dilution tests).In addition, 1 and 2 displayed comparable potencies in respect of sterol biosynthesis inhibition in Saccharomycopsis lipolytica and Pyricularia oryzae, the mode of action being primarily an inhibition of oxidative C14-demethylation.