1450823-91-2Relevant academic research and scientific papers
Intermolecular gold(I)-catalyzed alkyne carboalkoxylation reactions for the multicomponent assembly of β-alkoxy ketones
Schultz, Danielle M.,Babij, Nicholas R.,Wolfe, John P.
, p. 3451 - 3455 (2012)
A new gold(I)-catalyzed multicomponent synthesis of β-alkoxy ketones from aldehydes, alcohols, and alkynes is described. This atom economical synthesis was achieved through the use of the gold complex (SPhos)AuNTf 2 as a catalyst, and allows for the preparation of a diverse array of β-alkoxy ketone products. Mechanistic studies illustrate that these reactions proceed via gold(I)-catalyzed hydrolysis of the alkyne to an aryl ketone, which then undergoes an aldol reaction with an oxocarbenium ion generated in situ from the aldehyde and alcohol components.
