1450831-16-9

Upstream product

• 421-06-7 2-bromo-1,1,1-trifluoroethane 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 7515-27-7 3-(2-methylphenyl)prop-2-ynoic acid 
• 1178478-67-5 1-(3-chloroprop-1-ynyl)-2-methylbenzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 35851-37-7 3-(2-methylphenyl)-2-propyn-1-ol 

Relevant academic research and scientific papers

Method for preparing trifluoro-ethyl phenylacetylene compound

The invention provides a method for preparing a trifluoro-ethyl phenylacetylene compound. The method comprises the following step: in the presence of a copper catalyst, alkali and ligand, enabling potassium alkynyl trifluoroborate and tribromofluoroethane to react in a solvent, thereby obtaining the trifluoro-ethyl phenylacetylene compound. The method provided by the invention is capable of achieving high-yield synthesis of the trifluoro-ethyl phenylacetylene compound, and has good application prospects and industrial production potential.

Palladium-catalyzed decarboxylative trifluoroethylation of aryl alkynyl carboxylic acids

A trifluoroethylation of alkynes through a palladium-catalyzed decarboxylative coupling reaction was developed. When alkynyl carboxylic acids and ICH2CF3 were allowed to react with [Pd(? 3-allyl)Cl]2/XantPhos and Cs2CO3 in N,N-dimethylformamide (DMF) at 80 °C for 1 h, the desired products were formed in good yields. This catalytic system showed high functional group tolerance.

Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(i) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a hig