1450992-01-4Relevant academic research and scientific papers
Synthesis of bicyclic 2-pyridones by regioselective annulations of heterocyclic ketene aminals with anhydrides
Liu, Jin,Yan, Sheng-Jiao,Cao, Zheng-Mao,Cui, Shi-Sheng,Lin, Jun
, p. 103057 - 103064 (2016/11/13)
An efficient strategy for the synthesis of substituted bicyclic 2-pyridones is developed. The proposed approach is based on the regioselective N-acylation of heterocyclic ketene aminals (HKAs) with methacrylic anhydride or crotonic anhydride. The tolerance of the developed methodology allows for the construction of fused 2-pyridone ring systems in excellent yields with a variety of functional groups HKAs as synthons under neutral conditions.
A facile synthesis of tetrahydroimidazo[1,2-a]pyridines and tetrahydrobenzo[b]imidazo[1,2,3-ij][1,8]naphthyridines through NHC-catalyzed cascade annulations
Yao, Changsheng,Jiao, Weihui,Xiao, Zhaoxin,Xie, Yuanwei,Li, Tuanjie,Wang, Xiangshan,Liu, Rui,Yu, Chenxia
, p. 10801 - 10805 (2013/09/02)
A new efficient approach for the synthesis of tetrahydroimidazo[1,2-a] pyridines and tetrahydrobenzo[b]imidazo[1,2,3-ij][1,8]naphthyridines with biological significance was successfully developed through a NHC-catalyzed cascade C-C bond and C-N bond formation process. This new alternative approach for the assembly of these multi-functionalized nitrogen bridgehead-fused heterocycles features mild conditions, moderate to high yields and operational simplicity. The Royal Society of Chemistry 2013.
