14512-85-7

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-3-FLUOROPHENYL THIOCYANATE is utilized as a key intermediate in the synthesis of a variety of drugs and biologically active compounds. Its unique structural features contribute to the development of new pharmaceutical agents with potential therapeutic applications.
Used in Medicinal Chemistry and Drug Discovery Research:
In the realm of medicinal chemistry, 4-AMINO-3-FLUOROPHENYL THIOCYANATE serves as a valuable component in the design and synthesis of novel molecules with potential medicinal properties. Its presence in these molecules can influence their pharmacokinetics, pharmacodynamics, and overall therapeutic efficacy.
Used in Antifungal Applications:
4-AMINO-3-FLUOROPHENYL THIOCYANATE has been studied for its potential as an antifungal agent. Its ability to inhibit fungal growth suggests that it could be developed into a treatment for various fungal infections, offering a new avenue for combating resistant strains and expanding the arsenal of antifungal therapies.
Used in Agricultural Industry:
4-AMINO-3-FLUOROPHENYL THIOCYANATE's antifungal properties also extend to potential applications in agriculture, where it could be employed to protect crops from fungal diseases. This would contribute to maintaining crop health and yield, thereby supporting sustainable agricultural practices.

InChI:InChI=1/C7H5FN2S/c8-6-3-5(11-4-9)1-2-7(6)10/h1-3H,10H2

Upstream product

• 348-54-9 2-Fluoroaniline 
• 333-20-0 potassium thioacyanate 
• 1147550-11-5 ammonium thiocyanate 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 76180-33-1 [2-fluoro-4-(methylthio)phenyl]amine 
• 75867-50-4 2-fluoro-4-ethylthioaniline 
• 1378859-72-3 C₆H₅FNS^(1-)*Na⁽¹⁺⁾ 

Relevant academic research and scientific papers

Method for inducing thiocyanation of arylamine compound by visible light

The invention discloses a method for inducing thiocyanation of an arylamine compound by visible light. Specifically, in the atmosphere of oxygen or air, an arylamine compound, an ammonium thiocyanatecompound and copper chloride dihydrate are added into a

N -Thiocyanato-dibenzenesulfonimide: A new electrophilic thiocyanating reagent with enhanced reactivity

A novel electrophilic thiocyanating reagent, N-thiocyanato-dibenzenesulfonimide, was prepared and exhibited enhanced electrophilicity with a wide scope of substrates. Thus, it reacted with activated aromatics such as phenols, indoles, anilines and anisoles without a catalyst giving the corresponding thicyanate derivatives in high yields, while TfOH for unactivated arenes and hetero aromatics and Zn(OTf)2 for ketones was used as the catalyst, respectively. It is noteworthy that internal alkenes and styrenes were bifunctionalized giving 1,2-amino thiocyanates in high yields.

Copper-Catalyzed Aerobic Oxidative Regioselective Thiocyanation of Aromatics and Heteroaromatics

A copper-catalyzed aerobic oxidative reaction between aromatics or heteroaromatics with KSCN is developed by using O2 as the oxidant. The combination of Cu(OTf)2, N,N,N′,N′-tetramethylethylenediamine (TMEDA) and BF3·Et2O provides an efficient catalytic system, affording substituted thiocyanation products and 2-aminobenzothiazoles in excellent yields. The reaction also possesses a good functional group tolerance for both strong electron-withdrawing and electron-donating groups.

Transition-metal-free regioselective thiocyanation of phenols, anilines and heterocycles

An expedient direct and regioselective thiocyanation of phenols, anilines and heterocycles is described. Transformation is realized via the direct C[sbnd]H functionalization under transition metal free conditions at ambient temperature in excellent yields. Method proved to be monoselective and variety of functional groups tolerated the reaction conditions. The practicality of the protocol is demonstrated in gram scale synthesis of a precursor of PPAR δ agonist in excellent yield.

4-(TRICHLOROMETHYLTHIO)ANILINE, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING 4-(TRIFLUOROMETHYLTHIO)ANILINE

There are provided a 4-(trichloromethylthio)aniline represented by the general formula (II): wherein R1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 each independently represents a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a perfluoroalkyl group having 1 to 3 carbon atoms, R3 represents a formyl group, an acetyl group, or a trifluoroacetyl group, and m represents an integer of 0 to 4, a method for producing the same, and a method for producing a 4-(trifluoromethylthio)aniline derivative using the 4-(trichloromethylthio)aniline. It becomes possible to produce a 4-(trifluoromethylthio)aniline with a high yield by using raw materials that can easily be obtained industrially and using general purpose production facilities.

Heterocyclic Compounds as MEK Inhibitors

The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.

4-HYDROXYQUINOLINE-3-CARBOXAMIDES AND HYDRAZIDES AS ANTIVIRAL AGENTS

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

N-(4-substituted phenyl)-anthranilic acid hydroxamate esters

The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

Substituted-4-alkylthioalkane-sulfonanilides and operatives

Alkane- and monohaloalkane-sulfonanilides substituted in the para position by alkylthio, alkylsulfinyl and alkylsulfonyl groups and additionally substituted by halogen and optionally by trifluoromethyl and agriculturally acceptable salts thereof are useful herbicides.