145122-89-0

Basic information

• Product Name: 1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-phenyl-butan-1-one
• CAS NO: 145122-89-0
• Molecular Weight: 361.505
• Mol File: 145122-89-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-phenyl-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-phenyl-butan-1-one(145122-89-0)
• EPA Substance Registry System: 1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-phenyl-butan-1-one(145122-89-0)

Safety Data

• Hazardous Substances Data: 145122-89-0(Hazardous Substances Data)

Upstream product

• 94594-81-7 (E)-1-((3aR,6S,7aS)-8,8-dimethyl-2,2-dioxidotetrahydro-3H-3a,6-methanobenzo[c]isothiazol-1(4H)-yl)but-2-en-1-one 
• 591-51-5 phenyllithium 

Downstream Products

• 145122-93-6 N-[(1S,2S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-2-phenyl-propyl]-acetamide 
• 145122-91-4 (2S,2'S,3'S)-N-<2'-(hydroxyamino)-3'-phenylbutanoyl>bornane-10,2-sultam 
• 145122-92-5 (2S,2'S,3'S)-N-(2'-amino-3'-phenylbutanoyl)bornane-10,2-sultam 
• 25488-28-2 (2S,3S)-N-acetyl-β-methylphenylalanine 
• 145122-90-3 (2S,2'S,3'S)-N-<2'-(cyclohexylideneamino)-3'-phenylbutanoyl>bornane-10,2-sultam N-oxide 

Relevant articles and documents

Asymmetric Synthesis of α-Amino Acids and α-N-Hydroxyamino Acids from N-Acylbornane-10,2-sultams: 1-Chloro-1-nitrosocyclohexane as a Practical +> Equivalent

Successive treatment of N-acylsultams 3 with sodium hexamethyldisilazide, 1-chloro-1-nitrosocyclohexane (1), and aq.HCl gave diastereoisomerically pure, crystalline N-hydroxyamino-acid derivatives 5.These were converted into various amino acids 7, N-hydroxyamino acids 8, and an N-Boc-amino acid 9. (S,S)-Isoleucine (17) and (S,S)-2-acetamido-3-phenylbutyric acid (23) were obtained from N-crotonoylsultam 15 via 1,4-addition of an organomagnesium or organocopper reagent followed by enolate 'amination' with 1.