25488-28-2

Upstream product

• 25488-25-9 (2S,3S)-methylphenylalanine 
• 108-24-7 acetic anhydride 
• 145122-89-0 1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-phenyl-butan-1-one 
• 145122-92-5 (2S,2'S,3'S)-N-(2'-amino-3'-phenylbutanoyl)bornane-10,2-sultam 
• 591-51-5 phenyllithium 
• 106763-29-5 (2S,3S)-β-Methyl-N-phthaloylphenylalanin-methylester 
• 145122-93-6 N-[(1S,2S)-1-((1R,5S,7S)-10,10-Dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-2-phenyl-propyl]-acetamide 
• 71-43-2 benzene 
• 145122-90-3 (2S,2'S,3'S)-N-<2'-(cyclohexylideneamino)-3'-phenylbutanoyl>bornane-10,2-sultam N-oxide 
• 145122-91-4 (2S,2'S,3'S)-N-<2'-(hydroxyamino)-3'-phenylbutanoyl>bornane-10,2-sultam 

Downstream Products

• 7389-82-4 (Ξ)-3-(L_s-threo-2-acetylamino-3-phenyl-butyrylamino)-3-thiazol-2-yl-propionic acid methyl ester 

Relevant academic research and scientific papers

Asymmetric synthesis of N-(ethoxycarbonyl)-β-methylphenylalanine esters

Amination of the silyl ketene acetal of methyl (R)-3-phenylbutanoate (3) by photolysis with ethyl azidoformate gave the derivative of (2R,3S)-β-methylphenylalanine (4) with a low diastereomeric excess in spite of the resident chirality. Using the silyl ke

Asymmetric Synthesis of α-Amino Acids and α-N-Hydroxyamino Acids from N-Acylbornane-10,2-sultams: 1-Chloro-1-nitrosocyclohexane as a Practical +> Equivalent

Successive treatment of N-acylsultams 3 with sodium hexamethyldisilazide, 1-chloro-1-nitrosocyclohexane (1), and aq.HCl gave diastereoisomerically pure, crystalline N-hydroxyamino-acid derivatives 5.These were converted into various amino acids 7, N-hydroxyamino acids 8, and an N-Boc-amino acid 9. (S,S)-Isoleucine (17) and (S,S)-2-acetamido-3-phenylbutyric acid (23) were obtained from N-crotonoylsultam 15 via 1,4-addition of an organomagnesium or organocopper reagent followed by enolate 'amination' with 1.

Stereoselective Alkylation of Arenes with Threonine Trifluoromethanesulfonates

N-Phthaloylthreonine and -allothreonine methyl esters 3 react with trifluoromethanesulfonic anhydride / pyridine in dichloromethane to give threonine and allothreonine, respectively, trifluoromethanesulfonates 4 in quantitative yields.Arenes can be alkyla