145131-10-8 Usage
Type
Potent and selective inhibitor of leukotriene biosynthesis
Function
Acts as a mediator of inflammation by blocking the 5-lipoxygenase pathway
Mechanism
Prevents the formation of leukotrienes, which are pro-inflammatory mediators
Involvement
Leukotrienes are involved in asthma, allergic rhinitis, and other inflammatory conditions
Therapeutic Potential
Studied for its potential effects in asthma, rheumatoid arthritis, and other inflammatory diseases
Research Tool
Used to study the role of leukotrienes in various biological processes
Anti-cancer Properties
Demonstrated by inhibiting the growth of tumor cells
Check Digit Verification of cas no
The CAS Registry Mumber 145131-10-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,3 and 1 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 145131-10:
(8*1)+(7*4)+(6*5)+(5*1)+(4*3)+(3*1)+(2*1)+(1*0)=88
88 % 10 = 8
So 145131-10-8 is a valid CAS Registry Number.
145131-10-8Relevant articles and documents
New indole derivatives as ACAT inhibitors: Synthesis and structure-activity relationships
Bellemin,Decerprit,Festal
, p. 123 - 132 (2007/10/03)
A series of ureas containing the indole group were synthesized and assessed for their ability to inhibit arterial and intestinal ACAT and to lower plasma total cholesterol in a cholesterol-fed rat model. The structural modulations carried out in this series led to compounds which proved to be very active in both the inhibition of aortic ACAT in vitro and the inhibition of rat cholesterol intestinal absorption in vivo. Several compounds from this series exhibit a remarkable hypocholesterolaemic effect with ED25 less than 0.1 mg/kg po.
