445434-57-1

Upstream product

• 145133-11-5 methyl [1-(triphenylmethyl)-1H-imidazol-4-yl]acetate 
• 222978-03-2 4-cyano-3-fluorobenzylbromide 

Downstream Products

• 368435-73-8 [1-(4-cyano-3-fluorophenyl)-1H-imidazol-5-yl]acetic acid 

Relevant academic research and scientific papers

Inhibitors of prenyl-protein transferase

The present invention is directed to macrocyclic compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemothera-peutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

Inhibitors of prenyl-protein transferase

The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.