1451489-90-9

Upstream product

• 55271-06-2 3-(4-methoxyphenyl)-1H-indazole 
• 66938-29-2 (2-fluorophenyl)(4-methoxyphenyl)methanone 
• 944695-91-4 C₁₄H₁₃FO₂ 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 4217-54-3 9,10-dihydro-10-methylacridine 
• 1451494-91-9 C₁₆H₁₇N₂O⁽¹⁺⁾ 

Relevant academic research and scientific papers

Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile

A series of analogues of indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues of indazolium alkaloids to obtain hydride in acetonitrile were determined using an isothermal titration calorimeter (ITC) and electrochemical methods, respectively. The effects of molecular structure and substituents on the thermodynamic driving forces of the 6 steps were examined. Meanwhile, the oxidation mechanism of NADH coenzyme by indazolium alkaloids was examined using the chemical mimic method. The result shows that the oxidation of NADH coenzyme by indazolium alkaloids in vivo takes place by one-step concerted hydride transfer mechanism.