944695-91-4Relevant academic research and scientific papers
Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile
Lei, Nan-Ping,Fu, Yan-Hua,Zhu, Xiao-Qing
supporting information, p. 11472 - 11485 (2015/12/04)
A series of analogues of indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues of indazolium alkaloids to obtain hydride in acetonitrile were determined using an isothermal titration calorimeter (ITC) and electrochemical methods, respectively. The effects of molecular structure and substituents on the thermodynamic driving forces of the 6 steps were examined. Meanwhile, the oxidation mechanism of NADH coenzyme by indazolium alkaloids was examined using the chemical mimic method. The result shows that the oxidation of NADH coenzyme by indazolium alkaloids in vivo takes place by one-step concerted hydride transfer mechanism.
Fe(OTf)3-catalyzed α-benzylation of aryl methyl ketones with electrophilic secondary and aryl alcohols
Pan, Xiaojuan,Li, Minghao,Gu, Yanlong
supporting information, p. 268 - 274 (2014/01/06)
Acid-catalyzed Friedel-Crafts alkylation of 1,3-dicarbonyl compounds with electrophilic alcohols, is known to be an effective C-C bond forming reaction. However, until now, this reaction has not been amenable for α-alkylation of aryl methyl ketones because of the notoriously low nucleophilicities of these compounds. Therefore, α-alkylation of aryl methyl ketone relies on precious metal catalysts and also, the use of primary alcohols is mandatory. In this study, we found that a system composed of a Fe(OTf)3 catalyst and chlorobenzene solvent is sufficient to promote the title Friedel-Crafts reaction by using benzhydrols as electrophiles. 3,4-Dihydro-9-(2-hydroxy-4,4- dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-xanthen-1(2 H)-one was also applicable as an electrophile in this type of benzylation reaction. On the basis of this result, a three-component reaction of salicylaldehyde, dimedone, and aryl methyl ketone was also developed, and this provided an efficient way for the synthesis of densely substituted 4H-chromene derivatives. Copyright
Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization
Li, Hu,Zhu, Ru-Yi,Shi, Wen-Juan,He, Ke-Han,Shi, Zhang-Jie
supporting information, p. 4850 - 4853,4 (2012/12/12)
Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.
