66938-29-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4'-methoxybenzophenone is used as a building block for the synthesis of various pharmaceuticals and organic compounds. Its unique chemical properties make it a valuable component in the development of new drugs and therapeutic agents.
Used in Polymer and Resin Manufacturing:
2-Fluoro-4'-methoxybenzophenone is used as a photoinitiator in the manufacturing of various types of polymers and resins. Its ability to initiate polymerization reactions upon exposure to light makes it a useful component in the production of materials with specific properties and applications.
Used in Photochemistry:
2-Fluoro-4'-methoxybenzophenone is used as a photochemical reagent in various applications, such as in the synthesis of photoactive compounds and in the study of photochemical reactions. Its ability to absorb light and initiate chemical reactions makes it a valuable tool in the field of photochemistry.
Used in Research and Development:
2-Fluoro-4'-methoxybenzophenone is used as a research compound in the development of new materials, pharmaceuticals, and chemical processes. Its unique properties and potential applications make it an important compound for scientific investigation and innovation.

Upstream product

• 100-66-3 methoxybenzene 
• 393-52-2 2-Fluorobenzoyl chloride 
• 5720-07-0 4-methoxyphenylboronic acid 
• 446-52-6 2-Fluorobenzaldehyde 
• 67695-80-1 1,3-dioxoisoindolin-2-yl 4-methoxybenzoate 
• 1993-03-9 o-fluorophenylboronic acid 
• 100-09-4 4-methoxybenzoic acid 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 201230-82-2 carbon monoxide 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 696-62-8 para-iodoanisole 
• 445-29-4 o-fluoro-benzoic acid 
• 1072-85-1 o-fluorobromobenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 66938-39-4 (2-Fluoro-phenyl)-(4-methoxy-3-nitro-phenyl)-methanone 
• 86188-03-6 4-methoxy-2'-(4-methyl-1-piperidinyl)benzophenone 
• 101969-75-9 (2-fluorophenyl)(4-hydroxyphenyl)methanone 
• 66938-59-8 (4-amino-3-nitrophenyl)-(2-fluorophenyl)methanone 
• 138947-58-7 1-(2-fluorophenyl)-1-(4-methoxyphenyl)-2-propyn-1-ol 
• 1220532-01-3 C₁₈H₁₅NO₄ 
• 460747-42-6 (2-fluorophenyl)(4-hydroxy-3-iodophenyl)methanone 

Relevant academic research and scientific papers

Tetra- And Dinuclear Palladium Complexes Based on a Ligand of 2,8-Di-2-pyridinylanthyridine: Preparation, Characterization, and Catalytic Activity

Complexation of L [L = 5-phenyl-2,8-di-2-pyridinyl-anthyridine] with [Pd(CH3CN)4](BF4)2 and [Pd(CH3CN)3Cl](BF4) in a molar ratio of 1:2 rendered the corresponding dinuclear complexes [Pd2L (CH3CN)4](BF4)4 (1) and [Pd2L (CH3CN)2Cl2](BF4)2 (2), respectively. However, treatment of L with (COD)PdCl2 followed by anion exchange yielded a tetranuclear complex [Pd4L3Cl4](PF6)4(4a). Structures of these complexes are characterized by both spectroscopy and X-ray crystallography. Interconversion of these three complexes was studied via the manipulation of stoichiometric ratio of ligand to metal precursor. The catalytic activity of these complexes for carbonylative Suzuki-Miyaura cross-coupling was investigated. Complex 2 shows an excellent catalytic activity on the reaction of aryl iodide with arylboronic acid in the presence of atmospheric pressure of CO to give the corresponding benzophenones.

Continuous flow synthesis of diaryl ketones by coupling of aryl Grignard reagents with acyl chlorides under mild conditions in the ecofriendly solvent 2-methyltetrahydrofuran

An efficient continuous flow sequential synthesis of diaryl ketones was achieved by coupling of aryl Grignard reagents with acyl chlorides in the bio-derived “green” solvent 2-methyltetrahydrofuran (2-MeTHF) under mild reaction conditions (ambient temperature, 1 hour), allowing a safe and on-demand generation of 2-(3-benzoylphenyl)propionitrile with a productivity of 3.16 g hour?1

Method of utilizing continuous flow microreactor to synthesize benzophenone derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a method of utilizing a continuous flow microreactor to synthesize a benzophenone derivative. The methodincludes: using aryl Grignard reagent and acyl chloride as raw materials; at normal temperature, continuously synthesizing the benzophenone derivative in the microreactor; recycling a reaction solvent2-methyl tetrahydrofuran. Problems of environmental pollution and reaction operation safety caused by the fact that conventional Fridel-Crafts reaction is excessively dependent on reagents like aluminum trichloride, ferric trichloride and zinc dichloride are avoided, the defect that novel catalytic processes are expensive in catalytic reagent and harsh in operation condition is made up, and continuous synthesis of a medical intermediate ketoprofen nitrile is realized efficiently. The method has the advantages of high operation convenience, high reaction safety, high yield, high efficiency andreaction solvent reusability and is environment-friendly and efficient.

Synthesis and biological evaluation of negative allosteric modulators of the Kv11.1(hERG) channel

We synthesized and evaluated a series of compounds for their allosteric modulation at the Kv11.1 (hERG) channel. Most compounds were negative allosteric modulators of [3H]dofetilide binding to the channel, in particular 7f, 7h-j and 7p. Compounds 7f and 7p were the most potent negative allosteric modulators amongst all ligands, significantly increasing the dissociation rate of dofetilide in the radioligand kinetic binding assay, while remarkably reducing the affinities of dofetilide and astemizole in a competitive displacement assay. Additionally, both 7f and 7p displayed peculiar displacement characteristics with Hill coefficients significantly distinct from unity as shown by e.g., dofetilide, further indicative of their allosteric effects on dofetilide binding. Our findings in this investigation yielded several promising negative allosteric modulators for future functional and clinical research with respect to their antiarrhythmic propensities, either alone or in combination with known Kv11.1 blockers.

Erbium trifluoromethanesulfonate catalyzed Friedel-Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation

Erbium trifluoromethanesulfonate is found to be a good catalyst for the Friedel-Crafts acylation of arenes containing electron-donating substituents using aromatic carboxylic acids as the acylating agents under microwave irradiation. An effective, rapid and waste-free method allows the preparation of a wide range of aryl ketones in good yields and in short reaction times with minimum amounts of waste.

Elemental step thermodynamics of various analogues of indazolium alkaloids to obtaining hydride in acetonitrile

A series of analogues of indazolium alkaloids were designed and synthesized. The thermodynamic driving forces of the 6 elemental steps for the analogues of indazolium alkaloids to obtain hydride in acetonitrile were determined using an isothermal titration calorimeter (ITC) and electrochemical methods, respectively. The effects of molecular structure and substituents on the thermodynamic driving forces of the 6 steps were examined. Meanwhile, the oxidation mechanism of NADH coenzyme by indazolium alkaloids was examined using the chemical mimic method. The result shows that the oxidation of NADH coenzyme by indazolium alkaloids in vivo takes place by one-step concerted hydride transfer mechanism.

Pd-NHC-catalyzed synthesis of diaryl ketones

With N-hetereocyclic carbene and palladium catalysis, diaryl ketones with a variety of functional groups that span from electron withdrawing to electron donating substitutions can be conveniently synthesized using the corresponding aryl boronic acid and N-acyloxyphthalimide.

One-pot synthesis of diarylmethanones through palladium-catalyzed sequential coupling and aerobic oxidation of aryl bromides with acetophenone as a latent carbonyl donor

A one-pot palladium-catalyzed synthesis of symmetrical and unsymmetrical diarylmethanones using acetophenone and aryl bromides as raw materials has been developed. In this reaction, acetophenone acts as a latent carbonyl donor and two pathways of palladium-catalyzed sequential coupling and aerobic oxidation are identified. The reaction is applicable to a spectrum of substrates and delivers the products in moderate to good yields. This method can be used for the synthesis of ketoprofen, a nonsteroidal anti-inflammatory drug, in a two-step procedure and 45% overall yield.

Synthesis of fluorenone derivatives through Pd-catalyzed dehydrogenative cyclization

Palladium-catalyzed dual C-H functionalization of benzophenones to form fluorenones by oxidative dehydrogenative cyclization is reported. This method provides a concise and effective route toward the synthesis of fluorenone derivatives, which shows outstanding functional group compatibility.

Synthesis of arylketones by ruthenium-catalyzed cross-coupling of aldehydes with arylboronic acids

The first ruthenium-catalyzed cross-coupling of aldehydes with arylboronic acids is reported. Various aliphatic and aromatic aldehydes are transformed to the corresponding arylketones. A total of 31 examples with moderate to excellent yields are presented, together with the results of an initial mechanistic investigation.