1451491-11-4

Upstream product

• 1187376-65-3 ethyl 6-methyl-2-methoxy-4-(4-methylphenyl)-1,4-dihydropyrimidine-5-carboxylate 
• 74-88-4 methyl iodide 
• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 3246-80-8 9-phenyl-9H-xanthene 
• 1451495-74-1 C₁₇H₂₁N₂O₃⁽¹⁺⁾ 

Relevant academic research and scientific papers

Elemental steps of the thermodynamics of dihydropyrimidine: a new class of organic hydride donors

25 Dihydropyrimidine derivatives, a new class of organo-hydrides, were designed and synthesized by the Biginelli reaction. For the first time, the thermodynamic driving forces of the six elemental steps to obtain a hydride in acetonitrile were determined by isothermal titration and electrochemical methods, respectively. The effects of molecular structures and substituents on these thermodynamic parameters were examined, uncovering some interesting structure-reactivity relationships. Both the thermodynamic and kinetic studies show that the hydride transfer from dihydropyrimidines to 9-phenylxanthylium (PhXn+ClO4-) prefers a concerted mechanism.