1187376-65-3

Upstream product

• 29427-58-5 O-methylisourea hemisulfate 
• 104-87-0 4-methyl-benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 24285-39-0 O-methylisourea hydrosulfate 

Downstream Products

• 1187376-87-9 ethyl 6-methyl-2-methoxy-3-(2-oxo-2-phenylethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1187376-90-4 ethyl 6-methyl-2-methoxy-3-([4-chlorophenyl]-2-oxoethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1187376-92-6 ethyl 6-methyl-2-methoxy-3-([4-methoxyphenyl]-2-oxoethyl)-4-(4-methylphenyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1451491-11-4 C₁₇H₂₂N₂O₃ 

Relevant academic research and scientific papers

Elemental steps of the thermodynamics of dihydropyrimidine: a new class of organic hydride donors

25 Dihydropyrimidine derivatives, a new class of organo-hydrides, were designed and synthesized by the Biginelli reaction. For the first time, the thermodynamic driving forces of the six elemental steps to obtain a hydride in acetonitrile were determined by isothermal titration and electrochemical methods, respectively. The effects of molecular structures and substituents on these thermodynamic parameters were examined, uncovering some interesting structure-reactivity relationships. Both the thermodynamic and kinetic studies show that the hydride transfer from dihydropyrimidines to 9-phenylxanthylium (PhXn+ClO4-) prefers a concerted mechanism.

Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates

Fifteen new ethyl 6-methyl-2-methoxy-3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates (6a-o) have been synthesized in a two step reaction. In first step ethyl acetoacetate, s-methylisourea and appropri