145153-06-6

Basic information

• Product Name: N-benzyl-4-hydroxymethylaniline
• Synonyms: N-benzyl-4-hydroxymethylaniline;(4-(Benzylamino)phenyl)methanol
• CAS NO: 145153-06-6
• Molecular Formula: C₁₄H₁₅NO
• Molecular Weight: 213.27
• Mol File: 145153-06-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 385.9°C at 760 mmHg
• Flash Point: 154.5°C
• Appearance: /
• Density: 1.162g/cm³
• Vapor Pressure: 1.2E-06mmHg at 25°C
• Refractive Index: 1.648
• CAS DataBase Reference: N-benzyl-4-hydroxymethylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-4-hydroxymethylaniline(145153-06-6)
• EPA Substance Registry System: N-benzyl-4-hydroxymethylaniline(145153-06-6)

Safety Data

• Hazardous Substances Data: 145153-06-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H15NO/c16-11-13-6-8-14(9-7-13)15-10-12-4-2-1-3-5-12/h1-9,15-16H,10-11H2

Upstream product

• 623-04-1 4-aminobenzenemethanol 
• 100-44-7 benzyl chloride 
• 1100835-73-1 4-(benzylideneamino)benzyl alcohol 
• 619-73-8 4-nitrobenzyl chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 100-46-9 benzylamine 
• 18282-51-4 4-iodo-benzyl alcohol 

Relevant articles and documents

Microsomal formation of N-benzyl-4-hydroxymethylaniline from N-benzyl-4-methylaniline

The in-vitro metabolism of N-benzyl-4-methylaniline was re-examined using male hamster and rabbit hepatic microsomes; both species generated N-benzyl-4-hydroxymethylaniline confirmed, by TLC and HPLC, comparison with authentic compound. Further confirmati

Porous polymeric ligand promoted copper-catalyzed C-N coupling of (hetero)aryl chlorides under visible-light irradiation

A porous polymeric ligand (PPL) has been synthesized and complexed with copper to generate a heterogeneous catalyst (Cu@PPL) that has facilitated the efficient C-N coupling with various (hetero)aryl chlorides under mild conditions of visible-light irradiation at 80 °C (58 examples, up to 99% yields). This method could be applied to both aqueous ammonia and substituted amines, and is compatible to a variety of functional groups and heterocycles, as well as allows tandem C-N couplings with conjunctive dihalides. Furthermore, the heterogeneous characteristic of Cu@PPL has enabled a straightforward catalyst separation in multiple times of recycling with negligible catalytic efficiency loss by simple filtration, affording reaction mixtures containing less than 1 ppm of Cu residue. [Figure not available: see fulltext.]

Oxalic amide ligands, and uses thereof in copper-catalyzed coupling reaction of aryl halides

The present invention provides oxalic amide ligands and uses thereof in copper-catalyzed coupling reaction of aryl halides. Specifically, the present invention provides a use of a compound represented by formula I, wherein definitions of each group are described in the specification. The compound represented by formula I can be used as a ligand in copper-catalyzed coupling reaction of aryl halides for the formation of C—N, C—O and C—S bonds.