145222-94-2

Basic information

• Product Name: 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one
• Synonyms: 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one
• CAS NO: 145222-94-2
• Molecular Weight: 902.128
• Mol File: 145222-94-2.mol

Chemical Properties

• CAS DataBase Reference: 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one(145222-94-2)
• EPA Substance Registry System: 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one(145222-94-2)

Safety Data

• Hazardous Substances Data: 145222-94-2(Hazardous Substances Data)

Upstream product

• 145222-86-2 7-(tert-Butyl-diphenyl-silanyloxymethyl)-5-methoxy-1,2,9,9a-tetrahydro-3aH-6-aza-cyclopenta[b]naphthalene-3,4-dione 
• 161321-63-7 7-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-methoxy-1,2,9,9a-tetrahydro-6-aza-cyclopenta[b]naphthalen-3-one 
• 145222-91-9 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-α-<1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthalenyl>-6H-cyclopentisoquinoline-8-methanol 
• 145222-92-0 <3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinolin-8-yl><1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthalenyl>methanone 
• 145222-85-1 ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate 
• 145222-88-4 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6,7-dihydro-1,9-dimethoxy-8H-cyclopentisoquinolin-8-one 
• 145222-90-8 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinoline-8-carboxaldehyde 
• 145222-89-5 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline 
• 155349-13-6 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinoline-8-methanol 
• 145222-84-0 ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-methyl-3-pyridinecarboxylate 
• 139219-30-0 <<3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenyl>oxy>triethylsilane 
• 139219-31-1 3-bromo-4,5,7,8-tetramethoxy-2-(phenylethynyl)-1-naphthalenol 
• 145222-87-3 7-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-methoxy-1,2-dihydro-6-aza-cyclopenta[b]naphthalen-3-one 
• 136008-96-3 2-bromo-1,4,5,6,8-pentamethoxy-3-(phenylethynyl)naphthalene 

Downstream Products

• 145222-95-3 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-3-hydroxy-3-(hydroxyphenylmethyl)-1',4,5,6,8,9,9'-heptamethoxyspiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one 
• 145222-96-4 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxyspiro<2H-benzindene-2,8'-<8H>cyclopentisoquinoline>-1,3-dione 

Relevant articles and documents

Total synthesis of crystalline (±)-fredericamycin A. Use of radical spirocyclization

Crystalline (±)-fredericamycin A (1) was synthesized using, as a key step, 5-exo-digonal radical closure of selenide 55. The selenide was generated from the corresponding ketone 54, itself assembled from two components: aldehyde 29 and bromonaphthalene 48

Total Synthesis of (+/-)-Fredericamycin A. Use of Radical Spirocyclization

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