145222-86-2

Upstream product

• 145222-84-0 ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-methyl-3-pyridinecarboxylate 
• 145222-82-8 6-Dibromomethyl-2-methoxy-4-methyl-nicotinic acid ethyl ester 
• 161321-62-6 6-Formyl-2-methoxy-4-methyl-nicotinic acid ethyl ester 
• 145222-83-9 ethyl 6-(hydroxymethyl)-2-methoxy-4-methyl-3-pyridinecarboxylate 
• 112463-87-3 ethyl 2-methoxy-4,6-dimethyl-3-pyridinecarboxylate 
• 930-30-3 cyclopent-2-enone 
• 145222-85-1 ethyl 6-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-2-methoxy-4-<(3-oxocyclopentyl)methyl>-3-pyridinecarboxylate 

Downstream Products

• 145222-87-3 7-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydroxy-5-methoxy-1,2-dihydro-6-aza-cyclopenta[b]naphthalen-3-one 
• 145222-93-1 <3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-(phenylseleno)-6H-cyclopentisoquinolin-8-yl><1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthalenyl>methanone 
• 145222-95-3 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-3-hydroxy-3-(hydroxyphenylmethyl)-1',4,5,6,8,9,9'-heptamethoxyspiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one 
• 145222-91-9 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-α-<1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthalenyl>-6H-cyclopentisoquinoline-8-methanol 
• 145222-92-0 <3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinolin-8-yl><1,4,5,6,8-pentamethoxy-3-(phenylethynyl)-2-naphthalenyl>methanone 
• 145222-94-2 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxy-3-(phenylmethylene)spiro<2H-benzindene-2,8'-<8H>cyclopentisoquinolin>-1(3H)-one 
• 145222-96-4 3'-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6',7'-dihydro-1',4,5,6,8,9,9'-heptamethoxyspiro<2H-benzindene-2,8'-<8H>cyclopentisoquinoline>-1,3-dione 
• 145222-88-4 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-6,7-dihydro-1,9-dimethoxy-8H-cyclopentisoquinolin-8-one 
• 145222-90-8 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinoline-8-carboxaldehyde 
• 145222-89-5 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-8-methylene-6H-cyclopentisoquinoline 
• 155349-13-6 3-<<<(1,1-dimethylethyl)diphenylsilyl>oxy>methyl>-7,8-dihydro-1,9-dimethoxy-6H-cyclopentisoquinoline-8-methanol 

Relevant academic research and scientific papers

Total Synthesis of (+/-)-Fredericamycin A. Use of Radical Spirocyclization

(+/-)-Fredericamycin A 1 is synthesized using 5-exo-digonal radical closure of selenide 15 (Scheme 2), and an unusual procedure for both selective demethylation of the advanced intermediate 22 and adjustment of the stereochemistry in the pentadienyl side