145223-69-4

Upstream product

• 124166-11-6 (S)-(1-benzyl-2,5-dioxo-pyrrolidin-3-yl)carbamic acid benzyl ester 
• 124223-92-3 (3S)-3-amino-1-benzylpyrrolidine-2,5-dione 
• 100-39-0 benzyl bromide 
• 114715-38-7 (3S)-1-benzyl-3-pyrrolidinamine 
• 100-52-7 benzaldehyde 
• 145223-68-3 (S)-1-Benzyl-3-{[1-phenyl-meth-(E)-ylidene]-amino}-pyrrolidine-2,5-dione 

Downstream Products

• 145223-78-5 (R)-N-Benzyl-N-((S)-1-benzyl-pyrrolidin-3-yl)-2-fluoro-2-phenyl-acetamide 
• 145223-70-7 (S)-N-Benzyl-N-((S)-1-benzyl-pyrrolidin-3-yl)-2-fluoro-2-phenyl-acetamide 

Relevant academic research and scientific papers

3-Aminopyrrolidine lithium amide in enantioselective: Addition of organolithium compounds onto aromatic aldehydes

New N,N'-disubstituted-3-aminopyrrolidines lithium amides have been used as chiral auxiliaries in the asymmetric condensation of n-butyllithium onto aromatic aldehydes, leading to e.e.s up to 73%.

Handy access to chiral N,N'-disubstituted 3-aminopyrrolidines

A new and rapid synthesis of (S)-3-aminopyrrolidines Z is proposed from N-protected (S)-Asparagine. Basic cyclization of methyl N-Z-(S)-Asparaginate 1 followed by one-pot N-benzylation directly leads to (S)-aminosuccinimide 3 which, after cleavage of the