1452391-01-3

Upstream product

• 10310-21-1 2-Amino-6-chloropurin 
• 1452390-84-9 (S)-2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)oxirane 
• 19916-73-5 2-Amino-6-benzyloxypurine 

Downstream Products

• 1452391-04-6 (S)-N-(9-(4-(bis(4-methoxyphenyl)(phenyl)methoxy)-2-hydroxybutyl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide 
• 1452391-02-4 (S)-N-(6-(benzyloxy)-9-(4-(bis(4-methoxyphenyl)(phenyl)-methoxy)-2-hydroxybutyl)-9H-purin-2-yl)isobutyramide 

Relevant academic research and scientific papers

Design, synthesis, biophysical and primer extension studies of novel acyclic butyl nucleic acid (BuNA)

A novel nucleic acid analogue called acyclic (S)-butyl nucleic acid (BuNA) composed of an acyclic backbone containing a phosphodiester linkage and bearing natural nucleobases was synthesized. Next, (S)-BuNA nucleotides were incorporated in DNA strands and their effect on duplex stability and changes in structural conformation were investigated. Circular dichroism (CD), UV-melting and non-denatured gel electrophoresis (native PAGE) studies revealed that (S)-BuNA is capable of making duplexes with its complementary strands and integration of (S)-BuNA nucleotides into DNA duplex does not alter the B-type-helical structure of the duplex. Furthermore, (S)-BuNA oligonucleotides and (S)-BuNA substituted DNA strands were studied as primer extensions by DNA polymerases. This study revealed that the acyclic scaffold is tolerated by enzymes and is therefore to some extent biocompatible.