(S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

Base Information

Chemical Name:(S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol
CAS No.:1452391-01-3
Molecular Formula:C₃₇H₃₇N₅O₅
Molecular Weight:631.731
Hs Code.:

Synonyms:(S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

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Chemical Property of (S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

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Technology Process of (S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

There total 2 articles about (S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1452390-84-9
(S)-2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)oxirane

: 19916-73-5
2-Amino-6-benzyloxypurine

: 1452391-01-3
(S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

Guidance literature:: 2-Amino-6-benzyloxypurine; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

(S)-2-(2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)oxirane; In N,N-dimethyl-formamide; at 110 ℃; for 12h;
DOI:10.1039/c3ob41244j

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 1452391-01-3
(S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethyl sulfoxide / N,N-dimethyl-formamide

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 12 h / 110 °C

With sodium hydride; dimethyl sulfoxide; In N,N-dimethyl-formamide;
DOI:10.1039/c3ob41244j

Reference yield: 67.0%

: 1452391-01-3
(S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol

: 79-30-1
isobutyryl chloride

: 1452391-02-4
(S)-N-(6-(benzyloxy)-9-(4-(bis(4-methoxyphenyl)(phenyl)-methoxy)-2-hydroxybutyl)-9H-purin-2-yl)isobutyramide

Guidance literature:: (S)-1-(2-amino-6-(benzyloxy)-9H-purin-9-yl)-4-(bis-(4-methoxyphenyl)(phenyl)methoxy)butan-2-ol; With pyridine; at 0 - 20 ℃; for 2h; Inert atmosphere;

isobutyryl chloride; at 0 ℃; for 4h;
DOI:10.1039/c3ob41244j