14527-42-5Relevant articles and documents
REACTIONS OF 2-TRIMETHYLSILYLYHIAZOLE WITH ACYL CHLORIDES AND ALDEHYDES SYNTHESIS OF NEW THIAZOL-2-YL DERIVATES
Medici, Alessandro,Fantin, Giancarlo,Fogagnolo, Marco,Dondini, Alessandro
, p. 2901 - 2904 (1983)
2-Trimethylsilylthiazole (1) undergoes ipso-substitution of the silyl group with various acyl chlorides and ethyl chloroformate affording 2-acylthiazoles (2)-(5) but adds by the carbon-silicon bond to the carbonyl group of aldehydes yielding thiazol-2-yl-trimethylsiloxy-methane derivates (7).
PYRAZOLO[4,3-D]THIAZOLE DERIVATIVES, AND PREPARATION AND THERAPEUTIC APPLICATION THEREOF
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Page/Page column 13, (2009/07/18)
The disclosure relates to a compound of formula (I): in which: R1, R2, R3 and R4 are as described in the specification, to compositions containing them and to their therapeutic use, especially as anticancer agen
1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
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Page 77, (2010/02/06)
Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.