16733-85-0

Usage

Uses

Used in Pharmaceutical Industry:
1,3-Thiazole-2-carboxamide is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of drugs with potent antimicrobial, antiviral, and antitumor effects. Its incorporation into drug molecules can enhance their therapeutic efficacy and selectivity against disease-causing agents.
Used in Agrochemical Industry:
In the agrochemical sector, 1,3-Thiazole-2-carboxamide is utilized as a building block in the creation of pesticides and other crop protection agents. Its antimicrobial properties make it a valuable component in developing compounds that protect crops from diseases and pests, thereby ensuring higher yields and food security.
Used in Chemical Research:
1,3-Thiazole-2-carboxamide is also used as a subject of chemical research to explore its potential applications and to understand its mechanisms of action. Researchers investigate its interactions with biological targets and its capacity to be modified or combined with other chemical entities to create new molecules with improved properties or novel therapeutic uses.
Used in Therapeutic Development:
1,3-Thiazole-2-carboxamide is being studied for its potential as a direct therapeutic agent for the treatment of various diseases, particularly cancer and infectious diseases. Its multifaceted biological activities suggest that it could be a promising candidate for the development of new treatment options, offering patients more effective and targeted therapies.

InChI:InChI=1/C4H4N2OS/c5-3(7)4-6-1-2-8-4/h1-2H,(H2,5,7)

Upstream product

• 14527-42-5 thiazole-2-carboxylic acid ethyl ester 
• 3034-53-5 2-bromo-1,3-thiazole 
• 3019-71-4 Trichloroacetyl isocyanate 
• 1452-16-0 thiazole-2-carbonitrile 
• 3581-87-1 2-methylthiazole 
• 16733-90-7 1,3-thiazole-2-carbohydrazide 
• 14190-59-1 1,3-thiazole-2-carboxylic acid 

Downstream Products

• 1452-16-0 thiazole-2-carbonitrile 
• 10200-59-6 Thiazole-2-carbaldehyde 
• 14542-12-2 (1,3-thiazol-2-yl)methanol 

Relevant academic research and scientific papers

Trash to treasure: Eco-friendly and practical synthesis of amides by nitriles hydrolysis in WepPA

The hydration of nitriles to amides in a water extract of pomelo peel ash (WEPPA) was realized with moderate to excellent yields without using external transition metals, bases or organic solvents. This reaction features a broad substrate scope, wide functional group tolerance, prominent chemoselectivity, and good reusability. Notably, a magnification experiment in this bio-based solvent at 100 mmol further demonstrated its practicability.

Copper catalysed direct amidation of methyl groups with N-H bonds

An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.

Preparation of primary amides from functionalized organozinc halides

Organozinc halides, which are prepared either by direct zinc insertion or halogen-magnesium exchange and subsequent transmetalation with ZnCl2, react smoothly with commercially available trichloroacetyl isocyanate to give, after hydrolysis, the corresponding primary amides. This method is compatible with a variety of functional groups such as an ester or a cyano group. Also heterocyclic-, alkenyl, and acetylenic zinc reagents are converted to the corresponding primary amides under these conditions.

THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS

The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological dise