1452772-87-0

Upstream product

• 626-39-1 1,3,5-trisbromobenzene 
• 13994-57-5 3-methoxy-3-methylbut-1-yne 

Downstream Products

• 1452772-89-2 1,3-diethynyl-5-(3-methoxy-3-methylbut-1-yn-1-yl)benzene 
• 1452772-90-5 1,3-bis(1-isopropyl-1H-1,2,3-triazol-4-yl)-5-(3-methoxy-3-methylbut-1-yn-1-yl)benzene 
• 1452772-91-6 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(1-phenyl-1H-1,2,3-triazol-4-yl)benzene 
• 1452772-92-7 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(1-(3,5-bis(trifluoromethyl)-phenyl)-1H-1,2,3-triazol-4-yl)benzene 
• 1452772-93-8 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(4-N,N-dimethylaniline-1H-1,2,3-triazol-4-yl)benzene 
• 1452772-94-9 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(1-perfluorophenyl-1H-1,2,3-triazol-4-yl)benzene 
• 1452773-12-4 5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-bis(4-(3,5-bis(trifluoromethyl)-phenyl)-1H-1,2,3-triazol-1-yl)benzene 
• 1452772-88-1 ((5-(3-methoxy-3-methylbut-1-yn-1-yl)-1,3-phenylene)bis(ethyne-2,1-diyl))bis(trimethylsilane) 

Relevant academic research and scientific papers

Chiral helical oligotriazoles: New class of anion-binding catalysts for the asymmetric dearomatization of electron-deficient N -heteroarenes

Helical chirality and selective anion-binding processes are key strategies used in nature to promote highly enantioselective chemical reactions. Although enormous efforts have been made to develop simple helical chiral systems and thus open new possibilities in asymmetric catalysis and synthesis, the efficient use of synthetic oligo- and polymeric helical chiral catalysts is still very challenging and rather unusual. In this work, structural unique chiral oligotriazoles have been developed as C-H bond-based anion-binding catalysts for the asymmetric dearomatization of N-heteroarenes. These rotational flexible catalysts adopt a reinforced chiral helical conformation upon binding to a chloride anion, allowing high levels of chirality transfer via a close chiral anion-pair complex with a preformed ionic substrate. This methodology offers a straightforward and potent entry to the synthesis of chiral (bioactive)heterocycles with added synthetic value from simple and abundant heteroarenes.

Chiral Triazoles in Anion-Binding Catalysis: New Entry to Enantioselective Reissert-Type Reactions

Easily accessible and tunable chiral triazoles have been introduced as a novel class of C-H bond-based H-donors for anion-binding organocatalysis. They have proven to be effective catalysts for the dearomatization reaction of different N-heteroarenes. Although this dearomatization approach represents a powerful strategy to build chiral heterocycles, to date only a few catalytic methods to this end exist. In this work, the organocatalyzed enantioselective Reissert-type dearomatization of isoquinoline derivatives employing a number of structurally diverse chiral triazoles as anion-binding catalysts was realized. The here presented method was employed to synthesize a number of chiral 1,2-dihydroisoquinoline substrates with an enantioselectivity up to 86:14 e.r. Moreover, a thorough study of the determining parameters affecting the activity of this type of anion- binding catalysts was carried out.

"Click" bis-triazoles as neutral C-H?anion-acceptor organocatalysts

A new player on the field! "Click" bis-triazoles have been introduced as a highly efficient new class of neutral C-H?anion-binding organocatalysts (see scheme). DFT and NMR studies were used to confirm this activation modus and identify the optimal catalyst. Copyright